Mechanisms for Laser-Induced Rejuvenation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Fractionated Laser Resurfacing.
- Who it may be relevant to
- Registry conditions: Skin Cancer. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
It has shown that laser wounding of geriatric skin protects it against skin cancer. The purpose of this study is to determine the origin of cells called fibroblasts which are present after treatment with Fractionated Laser Resurfacing (FLR). These cells restore a youth-like ultraviolet B (UVB) response, but where they come from is currently unknown. The study recruits subjects who are scheduled to undergo abdominoplasties to investigate the origin of those cells stimulated by laser treatment.
Interventions
- Device Fractionated Laser Resurfacing
A rejuvenating laser that makes tiny holes in the very superficial part of the skin.
Primary outcome measures
- To test if the new fibroblasts that develop in response to fractionated laser resurfacing (FLR) wounding are derived from blood-derived monocytes. [Time frame: 2 weeks prior to skin removal and 1 week prior to skin removal]
- To test if possible cells transitioning from monocytes to fibroblasts are found in the top part of the dermis (papillary dermis). [Time frame: 2 weeks prior to skin removal and 1 week prior to skin removal]
Secondary outcome measures (3)
- To define the number and types of cells populating the skin following fractionated laser resurfacing (FLR) wounding [Time frame: 2 weeks prior to skin removal and 1 week prior to skin removal]
- To define the locations of the number of cells populating in the skin following fractionated laser resurfacing (FLR) wounding [Time frame: 2 weeks prior to skin removal and 1 week prior to skin removal]
- To define the locations of the types of cells populating in the skin following fractionated laser resurfacing (FLR) wounding [Time frame: 2 weeks prior to skin removal and 1 week prior to skin removal]
Eligibility criteria
Inclusion criteria
- Adult males and females 18 and older
- Able to comprehend procedures and risks
- Planning to undergo abdominoplasty surgery
- Minimum amount of skin to be removed is 50 x 20cm
Exclusion criteria
- Medical history of not well-controlled diabetes. This is defined as a subject who needs high doses of insulin, recent history of hospitalization for diabetes-related complications, or poor wound health as evidenced by diabetic ulcers. Subjects who have been deemed healthy enough for abdominoplasty surgery would tend to suggest that their diabetes should not be an issue. However, if the subjects have diabetic complications as outlined above, they could affect the wound healing which is the object of this protocol so they would be excluded.
- Pregnant or nursing
- History of pathologically abnormal wound healing such as keloidal scars
- Existing tattoos on the abdomen that are so extensive that they could interfere with the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
United States · 1 center
- Pharmacology Translational Unit — Fairborn
Identifiers
NCT: NCT06489301 · 2023-312