LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Motor imagery, Action reading, Motor localizer.
- Who it may be relevant to
- Registry conditions: Corticospinal Excitability, Cortical Activation. Basic parameters: 18 years — 40 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.
Interventions
- Other Motor imagery
Participants were asked to imagine arm or foot movements. - Other Action reading
Participants were asked to read sentences involving arm or foot movements - Other Motor localizer
Participants were asked to perform arm or foot movements
Primary outcome measures
- Level of corticospinal excitability [Time frame: 1 hour and 30 minutes]
- Cortical activation (BOLD signal) [Time frame: 1 hour]
Eligibility criteria
Inclusion criteria
- persons who have given written consent,
- healthy subjects
- subjects reading and understanding French
- right-handed,
- affiliated with a social security system,
- between 18 and 40 years old,
- had completed the TMS inclusion questionnaire or had undergone a medical examination prior to participation in the MRI study.
Exclusion criteria
- Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,
- Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,
- Characterized psychiatric pathology,
- Ingestion of alcohol prior to the examination,
- Persons covered by articles L1121-5 to L1121-8 of the CSP,
- Presence of contraindications to MRI or TMS.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
France · 2 centers
- CHU Grenoble Alpes — Grenoble
- Université de Bourgogne — Dijon
Identifiers
NCT: NCT06478303 · 38RC23.0349 · 2023-A02322-43