Microwave Ablation Versus Liver Resection for Intrahepatic Cholangiocarcinoma
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Microwave ablation (MWA) versus Liver Resection (LR).
- Who it may be relevant to
- Registry conditions: Overall Survival, Disease-free Survival. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Microwave Ablation Versus Liver Resection for Intrahepatic Cholangiocarcinoma Within Milan Criteria
Overview
Thermal ablation has been recommended by worldwide guidelines as first-line treatment for hepatocellular carcinoma (HCC), while evidence regarding its efficacy for primary intrahepatic cholangiocarcinoma (iCCA) is lacking. The goal of this observational study is to study the efficacy of ablation in treating iCCA by comparing its prognosis with surgery. The main questions it aims to answer are: * Whether microwave ablation could achieve similar efficacy with liver resection in treating iCCA * What is the risk factor for ablation or surgery in treating iCCA * What kind of iCCA patients could receive ablation as their first-line treatment In this real-world multicenter cohort study, we will collect data of iCCA patients from hospitals who underwent microwave ablation (MWA) or liver resection (LR) for tumors within Milan criteria. Survival will be compared between patients treated by MWA or LR.
Interventions
- Procedure Microwave ablation (MWA) versus Liver Resection (LR)
Microwave ablation (MWA) is one of the newer modality of thermal ablation and has proven its safety and efficacy in the management of the tumors amenable for ablation for primary and metastatic diseases. Liver resection is a surgery to remove part of the liver to eradicate tumors.
Primary outcome measures
- Overall survival [Time frame: More than 3 years]]
- Disease-free survival [Time frame: More than 3 years]
Eligibility criteria
Inclusion criteria
- pathologically diagnosed iCCA based on the WHO classifications;
- curative-intent liver resection or microwave ablation;
- tumor within Milan criteria, namely single tumor ≤5cm in maximum diameter; multiple tumors ≤3 in number and each ≤3cm; no evidence of major vascular/hilar invasion, extrahepatic/lymphatic metastasis or other malignancies;
- age ≥18 years.
Exclusion criteria
Patients not meeting any one of the inclusion criteria were excluded.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Chinese PLA General Hospital — Beijing
Publications
- Pang C, Li J, An C, Wang Z, Li Z, Chen Q, Qi R, Xiao F, Liu J, Gao X, Li M, Lv H, Li D, Liu X, Hua G, Yang M, Liang F, Yu J, Liang P. Survival Outcomes of Microwave Ablation Compared with Repeat Liver Resection in the Treatment of Recurrent Intrahepatic Cholangiocarcinoma. Radiology. 2026 Jan;318(1):e243254. doi: 10.1148/radiol.243254. PMID 41528222
Identifiers
NCT: NCT06462742 · S2024-0606