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Recruiting NCT06459635

Migraine Attack Pain Phase Prediction Study

— Observational Migraine Migraine Headache Migraine Disorders Migraine Without Aura

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Migraine, Migraine Headache, Migraine Disorders, Migraine Without Aura. Basic parameters: 18 years — 65 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Spain
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Prediction Study of the Pain Phase of Migraine Attacks in Patients With Episodic Migraine

Overview

The study of the ability to predict pain in a migraine attack, through premonitory symptoms and through an ambulatory monitoring device through real-time recording of hemodynamic variables, is one of the strategic lines of research of the unit. of Headaches at the Hospital de La Princesa since 2013 together with the Complutense and Polytechnic University of Madrid. Their results have been reflected in various publications (Pagán J, et al. Sensors 2015; Gago-Veiga AB, et al. J Pain Res 2018) and have promoted the creation of several invention patents.

Detailed description

Patients with episodic migraine will be recruited from the monographic headache clinics of the 7 centers participating in the study. These patients, for a maximum period of 2 months, must monitor their hemodynamic variables with a wearable device and record all the clinical characteristics of their migraine attacks. Subsequently, with these records, an individualized algorithm will be created for each patient that aims to predict the onset of the migraine attack.

Primary outcome measures

  • Development of a prediction strategy for the onset of migraine [Time frame: From the beginning of treatment, which is the initial visit, to 2 months of follow-up]
Secondary outcome measures (3)
  • Posibility of predict the onset of pain in a migraine attack [Time frame: From the beginning of treatment, which is the initial visit, to 2 months of follow-up]
  • Individualized prediction algorithm [Time frame: From the beginning of treatment, which is the initial visit, to 2 months of follow-up]
  • Effectiveness of the prediction model [Time frame: From the beginning of treatment, which is the initial visit, to 2 months of follow-up]

Eligibility criteria

Inclusion criteria

  • Age between 15 years and 69 years.
  • Diagnosed with migraine by a headache neurologist and according to the criteria proposed by ICHD-3.
  • History of migraine of at least 1 year of evolution.
  • Normal neurological examination.
  • Have given your informed consent.
  • Be able to describe your clinical situation and the characteristics of your headache.
  • Have an average of 10 to 14 migraine days per month in the three months prior to inclusion (high-frequency episodic migraine).
  • User-level management capacity of "smartphone" type electronic devices.
  • Be able to complete two months of study follow-up.

Exclusion criteria

  • Presence of another type of headache, with the exception of headache due to excessive use of analgesic medication.
  • Cognitive deficiency or any other pathology that may prevent or make it difficult for the patient to perform the study correctly.
  • Neurological focus in the examination.
  • Pregnancy or breastfeeding period.
  • Patients with known heart disease or bronchopathy, Sjögren\'s syndrome, diabetes mellitus, or hypo/hyperthyroidism.
  • Carriers of pacemakers, neurostimulators or any other electronic device that is considered to make the interpretation of biometric records difficult.
  • Anatomical problem that makes the use of the device impossible.
  • Patients in whom it is expected that a change in migraine preventive treatment or other usual treatment will be possible during the study period.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Case-control

Study locations

Spain · 1 center
  • Hospital Universitario de La Princesa — Madrid

Publications

  • Gago-Veiga AB, Pagan J, Henares K, Heredia P, Gonzalez-Garcia N, De Orbe MI, Ayala JL, Sobrado M, Vivancos J. To what extent are patients with migraine able to predict attacks? J Pain Res. 2018 Sep 27;11:2083-2094. doi: 10.2147/JPR.S175602. eCollection 2018. PMID 30310310
  • Pagan J, De Orbe MI, Gago A, Sobrado M, Risco-Martin JL, Mora JV, Moya JM, Ayala JL. Robust and Accurate Modeling Approaches for Migraine Per-Patient Prediction from Ambulatory Data. Sensors (Basel). 2015 Jun 30;15(7):15419-42. doi: 10.3390/s150715419. PMID 26134103

Identifiers

NCT: NCT06459635 · 3513

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗