Personalized Exercise Treatments for Older Veterans With Motoric Cognitive Risk Syndrome
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Functional Power Training (FPT), Music-Based Digital Therapy (MBDT), FPT + MBDT.
- Who it may be relevant to
- Registry conditions: Motoric Cognitive Risk Syndrome. Basic parameters: from 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Motoric Cognitive Risk Syndrome: Refining Treatment Strategies and Testing Feasibility to Personalize Treatment for Older Veterans
Overview
This study will begin to evaluate personalized preventative dementia treatments for Veterans at risk for developing dementia. The investigators will target Veterans with Motoric Cognitive Risk syndrome (MCR), which is characterized by slow gait speed and cognitive concerns (e.g., problems with memory or concentrations).
Detailed description
This study will involve therapeutic exercise treatments for Veterans with pre-clinical dementia syndrome. Participants will either participate in functional power training, music-based walking training, or a combination of both. The study will use a sequential multiple assignment, randomized trial (SMART) design. Successful completion of this study will lay the foundation for subsequent research trials, contributing to valuable evidence for personalized rehabilitation medicine for older Veterans.
Interventions
- Behavioral Functional Power Training (FPT)
Participants will receive twice weekly FPT, a progressive functional-based exercises that target optimizing leg force production and leg velocity. - Behavioral Music-Based Digital Therapy (MBDT)
Participants will receive twice weekly MBDT, a technology-driven gait training that is grounded in evidence-based rehabilitation treatment, rhythmic auditory stimulation. - Behavioral FPT + MBDT
For non-responders who were randomized to augment treatment, they will receive combined FPT and MBDT treatment.
Primary outcome measures
- Enrollment/Baseline [Time frame: Enrollment]
- Retention [Time frame: Baseline to end of 12-week treatment]
- Compliance [Time frame: Baseline to end of 12-week treatment]
- Acceptability [Time frame: End of 12-week treatment]
Secondary outcome measures (1)
- Gait Speed [Time frame: Baseline to end of 12-week treatment]
Eligibility criteria
Inclusion criteria
- Age 65
- Receiving VA primary care
- Community-dwelling
- Motoric Cognitive Risky Syndrome i. Slow gait speed ii. Subjective cognitive concerns/complaints
Exclusion criteria
- Non-English speaking
- Presence of a terminal disease
- Major medical problem
- Myocardial infarction or major surgery in the previous 3 months
- 3-point walking pattern
- Dementia diagnostic
- Mobility disability
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Sequential
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
United States · 1 center
- VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA — Boston
Identifiers
NCT: NCT06451874 · E5294-W