7.0T Magnetic Resonance Imaging Study of Parkinson's Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: 7T-MRI scaning.
- Who it may be relevant to
- Registry conditions: Parkinson's Diseases, MRI. Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This clinical trial study is conducted to detect the imaging characteristics of the patients with Parkinson's diseases (PD) by 7-Tesla (7T) magnetic resonance imaging (MRI).
Detailed description
In this study,we explored the imaging characteristics of PD. First, with the advantage of 7T, we detect the slight changes of PD with short diseases history compared with the healthy. Second, we investigate the different imaging characteristics in subtypes of PD, finding the effective neuroimaging biomarkers to distinguish different subtypes of PD. Finally, we take long time follow-up to evaluate the correlation between the imaging changes and clinical score alteration in PD.
Interventions
- Other 7T-MRI scaning
7T-MRI scaning
Primary outcome measures
- The change in motor symptoms in PD patients. [Time frame: 5 year after the conduction of clinical trial]
Secondary outcome measures (3)
- Functional connectivity alterations between individuals with different subtypes of PD and healthy subjects. [Time frame: 5 year after the conduction of clinical trial]
- Structural connectivity alterations between individuals with different subtypes of PD and healthy subjects. [Time frame: 5 year after the conduction of clinical trial]
- Clinical variables spectrum features linking to the motor symptoms and imaging spectrum features. [Time frame: 5 year after the conduction of clinical trial]
Eligibility criteria
Inclusion criteria
- the patients with PD who was diagnosed by the experienced neurologist specializing in movement disorders
Exclusion criteria
- the patients with brain disorders such as cerebrovascular disease, brain tumors, epilepsy, other neurodegenerative disease;
- psychiatric disorders with impaired cognitive function;
- contraindications to MRI.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
China · 1 center
- Chinese PLA General Hospital — Beijing
Identifiers
NCT: NCT06449404 · Parkinson's disease-ChinaPLAGH