Understanding New Semantic Memory Learnings Across the Lifespan
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Electroencephalography.
- Who it may be relevant to
- Registry conditions: Neurodevelopmental Changes (Childhood, Ageing). Basic parameters: 6 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The aim of this research is to specify the changes in brain connectivity (i.e. EEG phase synchronisation between brain regions) associated with semantic learning between individuals belonging to different age groups.
Detailed description
Semantic memory is a crucial concept in cognitive science. It has long been conceptualised as a static, amodal memory system containing knowledge about the world, concepts and symbols. Although recourse to this concept is inevitable, the mechanisms, both cognitive and neurobiological, that govern it are far from being elucidated. There are many debates and controversies in this fundamental field of cognitive science, and more specifically around the question of the acquisition and formation of knowledge in semantic memory. The literature on the development of semantic memory during ontogeny is full of contradictions.
A review of this literature highlights the many unanswered questions surrounding semantic memory. How quickly is information encoded and then consolidated into a format that justifies the term semantic knowledge? What are the neural bases underlying the formation of knowledge in semantic memory? How does semantic knowledge evolve through new episodes? How do these mechanisms evolve during ontogeny? To what extent can some semantic learning be preserved from cognitive ageing? In the face of these many questions, the literature highlights the lack of tasks enabling semantic memory to be approached in an operational manner and the need to specify the cerebral mechanisms involved at different ages of life.
The general hypotheses that will be tested as part of the ULIS project are as follows:
1. New semantic learning is possible independently of episodic memory processes. 2. This learning differs according to the age of the participants.
Interventions
- Device Electroencephalography
Phase synchrony during the completion of the semantic memory task
Primary outcome measures
- EEG Phase synchrony differences between age groups [Time frame: Through study completion, an average of 2 years]
Secondary outcome measures (1)
- Behavioral performance differences between age groups (semantic memory task) [Time frame: through study completion, an average of 2 years]
Eligibility criteria
Inclusion criteria
- Non-opposition by the participant or those exercising parental authority in the case of minors
- French language fluency (assessed by the investigating team)
- Absence of global cognitive deficit attested by a score on the MOCA (Montreal Cognitive Assessment) scale greater than or equal to 26/30 (test carried out at inclusion).
Exclusion criteria
- Person subject to a guardianship, curatorship or safeguard of justice measure
- Non affiliation to a social security scheme
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Case-control
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06442670 · 2024-A00167-40