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Recruiting NCT06432387

Coagulation Factors Alterations in Patients Undergoing Complex Thoraco-abdominal Aortic Aneurysm Repair

— Observational Thoraco-abdominal Aortic Aneurysm Repair Coagulation Factors Alterations Platelet Activation

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Patients undergoing complex thoraco-abdominal aortic aneurysm repair.
Who it may be relevant to
Registry conditions: Thoraco-abdominal Aortic Aneurysm Repair, Coagulation Factors Alterations, Platelet Activation. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Greece
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Coagulation Factors Alterations in Patients Undergoing Complex Thoraco-abdominal Aortic Aneurysm Repair (CoFA-TAAA); a Prospective Observational Study

Overview

This study will evaluate the impact of complex thoraco-abdominal aortic aneurysm repair in coagulation during the immediate postoperative period in patients undergoing omplex thoraco-abdominal aortic aneurysm repair.

Detailed description

Endovascular aneurysm repair of abdominal aorta activates a significant inflammation reaction and has an impact on coagulation. Platelet activation seems to have a major role in this prothrombotic and hypercoagulable state. In complex thoraco-abdominal aortic aneurysm repair the implants are more complexed and the duration of operation longer. The main hypothesis is that all the above have a greater impact on platelet activation and coagulation alterations.

The aim of this study is the evaluation of the impact of complex thoraco-abdominal aortic aneurysm repair in coagulation during the immediate postoperative period in patients undergoing omplex thoraco-abdominal aortic aneurysm repair.

Interventions

  • Other Patients undergoing complex thoraco-abdominal aortic aneurysm repair
    Patients undergoing complex thoraco-abdominal aortic aneurysm repair

Primary outcome measures

  • Coagulation status [Time frame: Day of surgery, 1st postoperative day, 4-5th postoperative day]
  • Myocardial injury after non cardiac surgery [Time frame: Day of surgery, 1st postoperative day, 4-5th postoperative day]
  • Acute kidney injury [Time frame: Day of surgery, 1st postoperative day, 4-5th postoperative day]
  • Post-implantation syndrome [Time frame: Day of surgery, 1st postoperative day, 4-5th postoperative day]
  • Major cardiovascular events [Time frame: Day of surgery, 1st postoperative day, 4-5th postoperative day]
  • Major cardiovascular events, implant failure and death of any cause [Time frame: 30 days, 3, 6, and 12 months postoperatively]

Eligibility criteria

Inclusion criteria

  • Consecutive patients undergoing complex thoraco-abdominal aortic aneurysm repair in University Hospital of Larissa, after informed consent will be included.

Exclusion criteria

  • Refuse to participate
  • Prior surgery within 3 months
  • ASA PS > 3
  • Known medical history of thrombophilia or functional platelet dysfunction

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

Greece · 2 centers
  • Larissa University Hospital — Larissa
  • University of Thessaly — Larissa

Identifiers

NCT: NCT06432387 · CoFA-TAAA

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗