Predictive Effect of TGF-β and INS-PI3K-AKT Related Proteins for POD in Diabetes Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: No intervention.
- Who it may be relevant to
- Registry conditions: Diabetes, Postoperative Delirium. Basic parameters: from 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Predictive Effect of TGF-β Combined With INS-PI3K-AKT Signaling Pathway Related Proteins (ADNP, MAP6, Pgc-1α) for POD in Diabetes Patients
Overview
To investigate the relationship between POD, TGF-β and INS-PI3K-AKT signaling pathway related proteins (ADNP, MAP6, PGC-1α) in diabetic patients
Detailed description
The study was a two-center, prospective，single blind (blinded to subjects and evaluators)，control, observational clinical study. Participants will collect 3 milliliters of blood from enrolled patients before surgery begins. The collected blood samples were processed and stored in -80℃ refrigerator. All samples were tested TGF-β and INS-PI3K-AKT signaling pathway related proteins (ADNP, MAP6, PGC-1α) by ELISA.
Interventions
- Other No intervention
No intervention
Primary outcome measures
- The correlation between preoperative plasma levels of TGF-β, ADNP, MAP6, PGC-1α and the incidence of delirium within 3 days after operation was analyzed. [Time frame: 2024-05 to 2026-06]
Eligibility criteria
Inclusion criteria
- Age ≥65 years
- History of diabetes ≥2 years and Glycated hemoglobin ≥6.5% or no history of diabetes and normal blood glucose
- The ASA rating is Class I to III
- The elderly patients of limited thoracic and abdominal tumor surgery
Exclusion criteria
- Refused to participate
- Previous history of schizophrenia, epilepsy, Parkinson's disease
- History of alcohol abuse or drug dependence
- Patients with ASA grade IV and above
- Severe visual or hearing impairment, can not cooperate with the completion of cognitive function tests
- Participants in other clinical trials within the last two months
- Patients with severe arrhythmia or cardiac dysfunction(EF<40%)
- There was a clear history of neurological and psychiatric problems or long-term use of sedatives or antidepressants
- History of cerebrovascular disease or brain surgery or trauma
- Severe liver dysfunction (Child-Pugh class C) or severe renal dysfunction (requiring dialysis)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
China · 2 centers
- The People's hospital of Qiannan — Duyun
- Zhejiang Cancer Hospital — Hangzhou
Identifiers
NCT: NCT06426953 · IRB-2024-467（IIT）