Photobiomodulation Therapy in Patients Receiving Total Knee Arthroplasty
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Photobiomodulation.
- Who it may be relevant to
- Registry conditions: Inflammation, Osteoarthritis, Post Operative Pain. Basic parameters: from 20 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Taiwan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
A Randomized Trial of Photobiomodulation Effect in Patients Receiving Total Knee Arthroplasty
Overview
Photobiomdoulation is the use of near-infrared light to relieve pain, stimulate healing and reduce inflammation. Swelling and inflammation is a common condition after orthopedics surgeries over extremity and spine. This study aim to evaluate the effect of photobiomodulation over patients after Total Knee Arthroplasty.
Detailed description
Patients aged over 20 after Total Knee Arthroplasty in our institution would be candidate for recruitment. The patients will be randomized to receive routine post operative care or photobiomodulation therapy. The swelling extent and subjective outcome will be recorded.
Interventions
- Device Photobiomodulation
Photobiomodulation therapy will be given daily start on the first day after surgery to post operative day 6
Primary outcome measures
- the change of bioimpedance [Time frame: the bioimpedance measured once daily since post operative day1 to day6 and at 2 weeks]
Secondary outcome measures (3)
- pain score (visual analogue score) [Time frame: once daily since post operative day1 to day6]
- active range of motion of knee [Time frame: once daily since post operative day1 to day6]
- 2 minute walk test [Time frame: once daily since post operative day1 to day6]
Eligibility criteria
Inclusion criteria
- total knee arthroplasty
Exclusion criteria
- open injury
- pregnancy
- wound without primary closure
- infection
- previous surgery over surgical site
- skin defect
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Taiwan · 1 center
- National Taiwan University Hospital, Hsin-Chu Branch — Hsinchu
Publications
- de Rezende MU, Varone BB, Martuscelli DF, Ocampos GP, Freire GMG, Pinto NC, de Sousa MVP. Pilot study of the effect of therapeutic photobiomodulation on postoperative pain in knee arthroplasty. Braz J Anesthesiol. 2022 Jan-Feb;72(1):159-161. doi: 10.1016/j.bjane.2021.07.040. Epub 2021 Nov 17. PMID 34800495
- Vassao PG, Renno AC, Smith BN, Bennett GB, Murphy M, Liebert A, Chow R, Laakso EL. Pre-Conditioning and Post-Operative Photobiomodulation Therapy by a Novel Light Patch System for Knee Arthroplasty: A Protocol for a Phase 1 Study. Photobiomodul Photomed Laser Surg. 2020 Apr;38(4):206-214. doi: 10.1089/photob.2019.4751. Epub 2020 Mar 18. PMID 32186975
- Chia WT, Wong TH, Jaw FS, Hsieh HC. The Impact of Photobiomodulation Therapy on Swelling Reduction and Recovery Enhancement in Total Knee Arthroplasty: A Randomized Clinical Trial. Photobiomodul Photomed Laser Surg. 2025 Feb;43(2):65-72. doi: 10.1089/photob.2024.0120. Epub 2025 Jan 9. PMID 39786308
Identifiers
NCT: NCT06426251 · 111-036-F