Characterization of Left Atrial Substrate in Patients With Ventricular Arrhythmias
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In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Left atrial electroanatomical mapping.
- Who it may be relevant to
- Registry conditions: Atrial Remodeling. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Belgium
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The goal of this observational study is to analyze the characteristics of left atrial electroanatomical maps in patients without a history of atrial fibrillation but with a high clinical risk of developing it, as indicated by the presence of structural heart disease or a CHA2DS2-VASc score ≥ 2 points. The study cohort will be compared to a historical cohort of patients with diagnosed atrial fibrillation in a propensity-matched fashion. The main questions it aims to answer are: * Are the left atrial electroanatomical changes a consequence or a precursor to the development of atrial fibrillation? * Are the left atrial electroanatomical findings different between patients with atrial fibrillation and those at high risk of developing it? * What is the prognostic impact of left atrial pathologic changes in patients without diagnosed atrial fibrillation in terms of cardiovascular outcomes?
Interventions
- Diagnostic test Left atrial electroanatomical mapping
Left atrial electroanatomical mapping (substrate and functional mapping)
Primary outcome measures
- Substrate characterization of the left atrium. [Time frame: 18 months]
- Functional characterization of the left atrium. [Time frame: 18 months]
Eligibility criteria
Inclusion criteria
- Absence of a prior history of atrial fibrillation or flutter.
- Patients presenting for ablation of any ventricular tachycardia related to structural heart disease or any ventricular arrhythmia with a CHA2DS2-VASc score ≥ 2.
Exclusion criteria
- Presence of thrombus in the left atrial appendage.
- Complications related to the index procedure.
- Insufficient quality of the left atrial electroanatomical map.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Belgium · 1 center
- Universitair Ziekenhuis Brussel — Jette
Identifiers
NCT: NCT06425822 · EC-2023-281