Pesticides and Parkinson´s Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: exposure to pesticides.
- Who it may be relevant to
- Registry conditions: Pesticide-Induced Parkinsonism. Basic parameters: 45 years — 55 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Spain
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Prevalence of Preclinical and Prodromal Parkinson´s Disease in Subjects Exposed to Pesticides
Overview
The aim of this project is to study whether people exposed to pesticides have a higher risk of developing PD. We will perform an epidemiological study determining the presence of pesticides in urine and comparing signs traditionally associated with PD in early forms.
Detailed description
Within different risk factors, pesticide exposure increases the risk of developing Parkinson's disease (PD) through epigenetic mechanisms by modifying the expression of genes related to PD and secondary mitochondrial dysfunction.We will conduct a cross-sectional prevalence study with cases (exposed to pesticides) and controls (not exposed to pesticides), randomly selecting 130 individuals in each group. Pesticide exposure will be determined through questionnaires.We will study the prevalence of preclinical and prodromal PD based on pesticide exposure, stratified by age and gender in the exposed, and non-exposed groups. Preclinical and prodromal PD will be assessed using: biological biomarkers and prodromal PD signs. Multivariate analyses will be employed to determine the risk of presenting early PD, adjusting for different clinical covariates. The results of this study will allow us to understand the early mechanisms associated with neurodegeneration and pesticides exposure.
Interventions
- Other exposure to pesticides
based on work exposures to pesticides
Primary outcome measures
- Prodromal PD [Time frame: over the last year]
Eligibility criteria
Inclusion criteria
- Farmers exposed to pesticides for cases
- No work exposure to pesticides for controls
Exclusion criteria
- Subjects without signed consent form
- Neurological significant conditions
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
Spain · 1 center
- Hospital Universitario de Burgos — Burgos
Identifiers
NCT: NCT06420310 · GRS 2682/A1/2023