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Recruiting NCT06420219

An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence

— Observational Head and Neck Carcinoma

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Non-Interventional Study.
Who it may be relevant to
Registry conditions: Head and Neck Carcinoma. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

This study evaluates the cell and biomarkers associated with the aggressive behavior of cancer.

Detailed description

PRIMARY OBJECTIVE:

I. High-resolution single-cell profiling of Cancer-associated fibroblasts (CAFs) in Human papillomavirus (HPV)+ Oropharyngeal Squamous Cell Carcinoma (OPSCC) and metastatic lymph nodes.

OUTLINE: This is an observational study.

Patients undergo photography, blood sample collection, tissue collection and have their medical records reviewed on study.

Interventions

  • Other Non-Interventional Study
    Non-interventional study

Primary outcome measures

  • Overall survival [Time frame: Up to 5 years]
  • Disease free survival [Time frame: Up to 5 years]

Eligibility criteria

Inclusion criteria

  • Diagnosis/disease status: New diagnosis of head and neck cancer
  • Allowable type and amount of prior therapy: No prior treatment
  • Age ≥ 18 years.
  • Ability to understand and the willingness to sign a written informed consent.

Exclusion criteria

  • Patients who have had treatment of head and neck cancer

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

United States · 1 center
  • USC / Norris Comprehensive Cancer Center — Los Angeles

Identifiers

NCT: NCT06420219 · 7H-23-4 · NCI-2024-01559 · 7H-23-4 · P30CA014089

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗