Register for Longitudinal Recording of Brain Function
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Patients With Brain Masses/Lesions. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Germany
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Register for Longitudinal Recording of Brain Function in Patients With Brain Diseases
Overview
The aim of this observational register study is to establish a registry that completely records and compiles the data from routinely performed technical examinations (navigated transcranial magnetic stimulation, intraoperative neuromonitoring and stimulation, MRI imaging including tractography and connectome) and clinical tests over time (pre-, intra- and postoperative, under adjuvant therapy, as part of follow-up care) of patients with intracranial masses and lesions.
Primary outcome measures
- Cognitive status [Time frame: until last patient FU up to 48 months]
- Language status [Time frame: until last patient FU up to 48 months]
- Motor status [Time frame: until last patient FU up to 48 months]
- cortical data [Time frame: until last patient FU up to 48 months]
- Fiber tracts [Time frame: until last patient FU up to 48 months]
- Fiber tracts [Time frame: until last patient FU up to 48 months]
- structural imaging (Connectome) [Time frame: until last patient FU up to 48 months]
Eligibility criteria
Inclusion criteria
- Intracranial lesion
- Age ≥ 18 years
- Written consent to participate in the study
Exclusion criteria
- Age < 18 years
- Patients not able to give consent
- Patients with intracranial ferromagnetic metal implants
- Patients with implanted electronic devices
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Germany · 1 center
- Department of Neurosurgery Heidelberg University Hospital — Heidelberg
Publications
- Schwendner M, Kram L, Zhang H, Krieg SM, Ille S. Preoperative nTMS-based mapping of a verbal semantic association task allows for the identification of extensive bihemispheric cortical and subcortical networks. J Neurooncol. 2025 Dec 8;176(1):108. doi: 10.1007/s11060-025-05355-9. PMID 41359250
Identifiers
NCT: NCT06401057 · Fun-Reg