The Impact of Smoking on the Prognosis of Elderly Surgical Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: none intervention.
- Who it may be relevant to
- Registry conditions: Delirium, Postoperative. Basic parameters: 60 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Impact of Smoking on Postoperative Delirium and Recovery Quality in Elderly Surgical Patients
Overview
Postoperative delirium is a common complication that frequently occurs in elderly patients after surgery. It not only increases the length of hospital stays and healthcare costs but also raises the incidence of postoperative cognitive dysfunction and even mortality. However, the underlying mechanisms of its onset are not yet fully understood. Evidence suggests that smoking can lead to gut microbiota dysbiosis and metabolic dysfunction, and the gut microbiota and its metabolites play a crucial role in cognitive function through the gut-brain axis. Yet, no studies have reported whether smoking could affect the occurrence of postoperative delirium and the quality of postoperative recovery through the gut microbiota. This study aims to observe the incidence of postoperative delirium and the postoperative recovery quality scores between smokers and non-smokers.
Detailed description
After obtaining approval from the ethics committee, patients are recruited, informed of the trial process and potential risks, and their informed consent is obtained and signed. According to the WHO definition, patients are classified into smokers (defined as those who smoke more than one cigarette per day continuously or cumulatively for six months; more than four times a week but averaging less than one cigarette per day) and non-smokers (never smoked). Fecal and blood samples are collected from both groups of patients preoperatively, and perioperative data is gathered. Postoperatively, an uninformed observer assesses the patients for delirium and recovery quality.
Interventions
- Other none intervention
No interventions are administered to either group of patients.
Primary outcome measures
- Postoperative delirium [Time frame: Within 3 days post-surgery]
- Quality of recovery in the first postoperative day [Time frame: Up to 24 hours after surgery.]
Eligibility criteria
Inclusion criteria
- Age >60 years;
- American Society of Anesthesiologists (ASA) preoperative anesthesia classification ASA Grades I and II;
- Undergoing elective surgery;
- Patients and their families are able to understand and complete various scoring scales and voluntarily sign informed consent.
Exclusion criteria
- Mini-Mental State Examination (MMSE) score <23;
- Preoperative biochemical tests indicate renal dysfunction or active liver disease;
- History of definite neurological or psychiatric disorders or history of taking corresponding medications before surgery;
- History of alcohol abuse or drug dependency;
- Taking antidepressant medications;
- American Society of Anesthesiologists (ASA) preoperative anesthesia classification > Grade II.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Affiliated hospital of Nantong University — Nantong
Identifiers
NCT: NCT06392308 · 2023-K213-01