Nationwide Research on the Rewilding of Kindergarten Yards
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Biodiversity, Playground equipment.
- Who it may be relevant to
- Registry conditions: Microbial Colonization, Atopic Dermatitis, Asthma in Children, Allergy. Basic parameters: 1 year — 5 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Finland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Nationwide Research on the Rewilding of Kindergarten Yards - Vahvistu
Overview
Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities that is associated with altered commensal microbiota and a rising burden of immunological disorders among urban children. The investigators will estimate how rewilding of kindergarten yards affects commensal microbiome, prevalence of allergies, asthma, atopic dermatitis and infections, cortisol levels, cognitive skills and plasma cytokine levels of children. Our specific aims are: To assess if rewilding diversifies health-associated skin, saliva and gut microbiota and reduces infectious diseases and atopic or allergic symptoms. Assess whether the rewilding has positive effects on cognitive skills. Assess whether the rewilding changes cortisol and plasma cytokine levels. The investigators will recruit altogether 320 (160 per treatment) study subjects aged between 1-5 to questionnaire study (Task 2), from which 120 study subjects will be analyzed more detailed using microbiological and blood samples (Task 1).
Interventions
- Other Biodiversity
In rewilding kindergartens, the yards are modified with biological elements, i.e., vegetation and plantation will be added to the yards. - Other Playground equipment
Playground equipment that increase the physical activity of children will be added to the kindergarten yards.
Primary outcome measures
- Skin Gammaproteobacteria [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
Secondary outcome measures (12)
- Cortisol levels [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
- Difference in diversity of skin, saliva and stool microbiota [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
- Microbial observed species richness [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
- Difference in taxonomies of skin, saliva and stool microbiota [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
- White blood cell distribution [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
- White blood cell transcriptomics [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
- Plasma cytokines [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
- Skin cytokines [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
- Infectious diseases [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
- Asthma symptoms [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
- Atopic dermatitis [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
- Allergy [Time frame: Baseline, 3 month, 1 year, 2 year, 3 year]
Eligibility criteria
Inclusion criteria
- Attendance in kindergarten
Exclusion criteria
- Use of antibiotics in the year before sampling
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
Finland · 2 centers
- Natural Resources Institute Finland — Helsinki
- Tampere University — Tampere
Identifiers
NCT: NCT06390878 · R24023