Childhood Early Oral Aging Syndrome: Prevalence, Etiological Factors, and Consequences on Occlusion

Official title

Childhood Early Oral Aging Syndrome: Prevalence, Associated Etiological Factors, and Consequences on Vertical Dimension of Occlusion (VDO): A Cross-Sectional Study

Overview

The Early Oral Aging Syndrome (EOAS) is a broad concept concerning changes in oral health caused by systemic diseases of different origins, which are related to the current lifestyle in the pediatric population. Enamel defects associated with intrinsic and extrinsic factors promote the acceleration of dental structure loss in an early manner, causing impairment of function, aesthetics, and quality of life. In this context, this study aims to identify the prevalence of early childhood tooth wear and its severity using the Early Childhood Oral Aging Syndrome (EOAS) index as a diagnostic and epidemiological survey instrument, considering current alterations found in the pediatric population and verifying possible factors associated with each severity level. Participants aged 3 to 6 years old, enrolled in the pediatric dentistry clinic of the University Nove de Julho, will be selected. Children with imperfect amelogenesis and dentinogenesis, genetic syndromes, and undergoing orthodontic treatment will be excluded from the research. A questionnaire on general health, sleep quality, nutrition, hygiene habits, and parafunctional habits will be administered. Subsequently, a clinical examination will be conducted using the new Early Childhood Oral Aging Syndrome (EOAS) index with scores ranging from 0 to 3 to assess dental wear and dental management, and scores I to III that should be used concomitantly in cases of enamel defects presence, in addition to measuring the Vertical Dimension of Occlusion (VDO). EOAS scores will be computed and statistically analyzed for deciduous dentition with a significance level of P\<0.05.

Interventions

• Behavioral Observation
  Identify the prevalence of early wear in primary dentition, using Childhood Early Oral Aging Syndrome (CEOAS) index. The CEOAS index involves scores of 0 to 3 for the assessment of tooth wear and dental management, whereas scores of I, II and III are used concomitantly in cases of the presence of enamel defects.

Primary outcome measures

• Assessment of Tooth Wear and Dental Management [Time frame: Baseline]
• Presence of Enamel Defects [Time frame: Baseline]
• Vertical Dimension of Occlusion [Time frame: Baseline]

Eligibility criteria

Inclusion criteria

• Children from three to six years of age with complete deciduous teeth;
• Children regularly enrolled for dental care at the Uninove pediatric dentistry clinic

Exclusion criteria

• Children with amelogenesis or dentinogenesis imperfecta
• Children undergoing orthodontic treatment
• Children with a genetic syndrome

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model

Case-crossover

Study locations

Brazil · 1 center

• Nove de Julho University — São Paulo

Publications

• Spinola SG, Sobral APT, Mandetta ARH, Gimenez T, Goncalves MLL, Soares PV, Santos EM, Imparato JCP, Horliana ACRT, Mesquita-Ferrari RA, Motta LJ, Fernandes KPS, Bussadori SK. Childhood early oral ageing syndrome: prevalence and association with possible aetiological factors and consequences for the vertical dimension of occlusion: protocol for a cross-sectional study. BMJ Open. 2024 Dec 23;14(12): PMID 39719276

Identifiers

NCT: NCT06381414 · ChildhoodEarlyOralAging

Primary sources (government registries)

• ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗