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Recruiting NCT06375564

Clinical Evaluation of 177Lu-AB-3PRGD2 in Various Solid Tumors With Integrin αvβ3 Positive Expression

Phase I Interventional Refractory Solid Tumor

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: 177Lu-AB-3PRGD2 radioligand therapy.
Who it may be relevant to
Registry conditions: Refractory Solid Tumor. Basic parameters: 18 years — 90 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

An Open-Label, Non-Randomized, Single-Center, Investigator-Initiated Trial to Determine the Effectiveness of 177Lu-AB-3PRGD2 in Various Solid Tumors With Integrin αvβ3 Positive Expression

Overview

This is an open-label, non-controlled, non-randomized study to assess the therapeutic efficacy of 177Lu-AB-3PRGD2 in patients with various solid tumors who will undergo radioligand therapy using 177Lu-AB-3PRGD.

Detailed description

Integrin αvβ3 is highly expressed in some tumor cells and neovascularization, which is an ideal target for diagnosis and treatment of solid tumors. 177Lu-AB-3PRGD2, is a kind of new drug based on independent research and development in China, providing an effective target for the treatment of tumors. All patients underwent whole-body 68Ga-RGD PET/CT for selection and accepted intravenous injection with a fixed dose of 2.96 GBq (80 mCi) of 177Lu-AB-3PRGD2 within one week. Treatment is planned for up to 4 cycles, and the time interval between cycles is 6 weeks. The primary endpoint assessed the preliminary treatment efficacy of 177Lu-AB-3PRGD2 used for radioligand therapy in patients with various advanced tumors. The secondary endpoint evaluates the safety of 177Lu-AB-3PRGD2.

Interventions

  • Drug 177Lu-AB-3PRGD2 radioligand therapy
    Radioligand therapy using 177Lu-AB-3PRGD2 80 mCi (2.96 GBq) will be performed 6-weekly. A maximum of 4 cycles will be administered.

Primary outcome measures

  • Objective response rate (ORR) [Time frame: At the end of Cycle 4 (each cycle is 42 days)]
Secondary outcome measures (1)
  • Incidence of treatment-related adverse events (safety and tolerability) [Time frame: At the end of Cycle 4 (each cycle is 42 days)]

Eligibility criteria

Inclusion criteria

  • Ability to understand and willingness to sign a written informed consent document.
  • Age 18 and older.
  • Confirmed unresectable or metastatic refractory cancer with measurable disease per RECIST (version 1.1) (i.e. at least 1 lesion > 1 cm or lymph node > 1.5 cm in short axis).
  • Progressive disease after multiple-lines treatment.
  • Eastern Cooperative Oncology Group Performance Status ≤ 3.
  • Participant must have completed prior therapy at least 2 weeks (washout period) before 68Ga-RGD PET/CT scan. Any clinically significant toxicity (with the exceptions of hair loss and sensory neuropathy) related to prior therapy resolved below Grade 2 or baseline. Completion of entry into 68Ga-RGD study and completion of the scan.
  • Hematologic parameters are defined as Absolute neutrophil count (ANC) ≥ 1000 cells/mm3 Platelet count ≥ 50,000/mm3 Hemoglobin ≥ 8 g/dL.
  • Blood chemistry levels defined as AST, ALT, alkaline phosphatase ≤ 5 times upper limit of normal (ULN) Total bilirubin ≤ 3 times ULN Creatinine ≤ 3 times ULN Able to remain motionless for up to 30-60 minutes per scan.

Exclusion criteria

  • Participant on any chemical anticoagulant including antiplatelet agents (excluding ASA).
  • Participants with Class 3 or 4 NYHA Congestive Heart Failure.
  • Clinically significant bleeding within two weeks before trial entry (e.g. gastrointestinal bleeding, intracranial bleeding).
  • Pregnant or lactating women.
  • Major surgery, defined as any surgical procedure that involves general anesthesia and a significant incision (i.e. larger than what is required for placement of a central venous access, percutaneous feeding tube, or biopsy) within 28 days before study day 1 or anticipated surgery within the subsequent 6 weeks.
  • Has an additional active malignancy requiring therapy within the past 2 years.
  • Active, uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy.
  • Psychiatric illness/social situations that would interfere with compliance with study requirements
  • Cannot undergo PET/CT scanning because of weight limits (350 lbs).
  • INR>1.2; PTT>5 seconds above UNL.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Treatment

Study locations

China · 1 center
  • The First Affiliated Hospital of Xiamen University — Xiamen

Identifiers

NCT: NCT06375564 · XMYY-2020KY067-05

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗