Investigating the Plasticity of Human Predictive Coding Through Neuromodulation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Occipital tACS at IAF-2Hz, Occipital tACS at IAF+2Hz, Frontal tACS at 4-7 Hz, Occipital tRNS.
- Who it may be relevant to
- Registry conditions: Human Brain and Cognition. Basic parameters: 18 years — 35 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Investigating the Plasticity of Human Predictive Coding Through Neuromodulation: an Interventional, Monocentric, Randomized, Single-blinded Study on Healthy Adult Volunteers
Overview
The hypothesis of the study is to investigate how different trm (tES) methods (transcranial Alternating Current Stimulation, tACS, and transcranial Random Noise Stimulation, tRNS) applied at different stimulation frequencies and networks can modulate the predictive mechanisms in human perception and cognition. This is an interventional, monocentric, cross-sectional randomized, single-blinded study on healthy adult volunteers, recruited through online advertisements, flyers and oral transmission. Volunteers will be recruited from the general population of young adults.
Interventions
- Procedure Occipital tACS at IAF-2Hz
tACS applied to occipital areas at 2 Hz below the individual alpha frequency (IAF) - Procedure Occipital tACS at IAF+2Hz
tACS applied to occipital areas at 2 Hz above the individual alpha frequency (IAF) - Procedure Frontal tACS at 4-7 Hz
tACS applied to frontal areas at 4-7 Hz - Procedure Occipital tRNS
tRNS applied to occipital brain regions - Procedure Frontal tRNS
tRNS applied to frontal brain regions - Procedure Sham/placebo tACS
tACS is activated only for 30 seconds and then turned off, thus resulting ineffective - Procedure Sham/placebo tRNS
tRNS is activated only for 30 seconds and then turned off, thus resulting ineffective
Primary outcome measures
- Behavioral measures [Time frame: During the procedure]
Eligibility criteria
Inclusion criteria
- Participant is willing and able to give informed consent for participation in the study.
- Aged 18-35 years.
- Normal or corrected to normal vision, as per anamnestic investigation.
Exclusion criteria
- Participants with a diagnosis of epilepsy (as per anamnestic investigation).
- Participants with major neurological disorders (as per anamnestic investigation).
- Participants that are currently under psychopharmacological treatment with tricyclic antidepressants (as per anamnestic investigation).
- Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants (as per anamnestic investigation).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Basic science
Study locations
Italy · 1 center
- Università Vita-Salute San Raffaele — Milan
Identifiers
NCT: NCT06374433 · PREDICOM-01