Longevity Families of the Netherlands
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Longevity, Familial Longevity, Extreme Longevity, Aging. Basic parameters: from 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Netherlands
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity. The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.
Primary outcome measures
- Identifying the genetic variants of Familial Longevity [Time frame: through study completion, an average of 2 years]
Secondary outcome measures (1)
- Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component [Time frame: through study completion, an average of 2 years]
Eligibility criteria
Inclusion criteria
- Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity
- Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity
Exclusion criteria
\-
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Family-based
Study locations
Netherlands · 1 center
- Leiden University Medical Center — Leiden
Identifiers
NCT: NCT06374069 · NL81887.058.23