Oral Manifestations in Egyptian Children With Short Stature
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Oral Manifestations, Short Stature. Basic parameters: 6 years — 12 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Oral Manifestations in a Group of Egyptian Children With Short Stature and a Group of Healthy Egyptian Children : A Cross Sectional Study
Overview
Children with short stature have been reported to show a higher prevalence of enamel hypoplasia, delayed tooth eruption, and malocclusion compared to children of normal growth status
Detailed description
Normal growth is a process in which a single cell develops into a fully grown adult. The growth rate decelerates from the embryonic stage to adulthood, except during puberty. Most adults fall within a narrow range of stature, typically between 1.5 to 2 meters. Variations in height among children are largely determined by a set of genes inherited from their parents. These genes influence stature distribution within the normal range for nearly 95% of the population, with variation generally being benign.
Short stature in children-defined as a height-for-age below -2 standard deviations (SD) from the WHO growth reference-typically corresponding to the 2.3rd percentile, though many texts use the 3rd percentile as the cutoff. Short stature can be assessed using various anthropometric instruments. The condition may be physiological, with no abnormalities other than stature (polygenic short stature), or pathological, resulting from systemic illnesses, nutritional deficiencies, psychosocial factors, hormonal imbalances, genetic disorders, or musculoskeletal pathologies. A subset of infants born small for gestational age (SGA) may be at risk of persistent short stature.
Children with short stature have been reported to show a higher prevalence of enamel hypoplasia, delayed tooth eruption, and malocclusion compared to children of normal growth status . These oral manifestations may result from shared pathogenic mechanisms, such as nutritional deficits, systemic disturbances during enamel formation, or hormonal imbalances affecting growth and development. A clearer understanding of these associations may enhance multidisciplinary screening and care.
This study aims to investigate the prevalence and characteristics of oral manifestations in Egyptian children with short stature, contributing to the limited regional data on this topic.
Primary outcome measures
- Dental enamel defects [Time frame: 3 months]
- Delayed dental eruption [Time frame: 3 months]
- Malocclusion [Time frame: 3 months]
- Dental caries experience [Time frame: 3 months]
Eligibility criteria
Inclusion criteria
- • - Egyptian children aged 6-12 years.
- \- Diagnosed with short stature (height-for-age < -2 SD based on WHO standards).
- \- Diagnosed and confirmed by a pediatric endocrinologist.
Controls:
- \- Age- and sex-matched children with normal height (height-for-age between -1 and +1 SD).
- \- Recruited from the same geographic and socioeconomic backgrounds.
Exclusion criteria
- 1- Presence of syndromic conditions (e.g., Turner syndrome, Down syndrome).
- 2- Chronic diseases (e.g., renal, cardiac, or endocrine conditions other than idiopathic short stature).
- 3- Long-term medication use known to affect growth or oral development.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Other
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06372366 · Oral signs ,short stature