The Acute T-Rex (Timing of Resistance Exercise) Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Resistance Exercise Timing.
- Who it may be relevant to
- Registry conditions: Diabetes Mellitus, Type 2, Insulin Resistance, Glucose Intolerance, Sleep Disturbance. Basic parameters: 50 years — 74 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Timing (AM v PM) of Acute Resistance Exercise on Glycemic Control in Older Adults: The Acute T-Rex Study
Overview
The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.
Interventions
- Behavioral Resistance Exercise Timing
1 resistance exercise session consisting of 3 sets, 10 repetitions per set, on 12 different exercises
Primary outcome measures
- Insulin sensitivity [Time frame: 1 day]
Secondary outcome measures (1)
- Sleep Duration [Time frame: 1 day]
Eligibility criteria
Inclusion criteria
- Men and women, all ethnicities, aged 50-74 years
- BMI ≥25 kg/m² and <45 kg/m²
- Weight stable (less than 5% change in the past 6 months)
- Generally healthy individuals
- Not meeting recommended activity guidelines for aerobic or resistance exercise
Exclusion criteria
- Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease
- Cancer treatment in the past 5 years
- Untreated thyroid disease or other medical conditions affecting weight or energy metabolism
- Current use of weight loss medication or other medications likely to impact energy balance
- Bariatric surgery or extensive bowel resection in the past 2 years
- Current or recent history (past 2 years) of eating disorder
- Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders
- Non-English speaking
- HbA1c >6.5%
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Double blind
- Primary purpose
- Prevention
Study locations
United States · 1 center
- University of Utah HPER E Buildling — Salt Lake City
Identifiers
NCT: NCT06366399 · 00156659