Retrospective Study of Patients with Acute Presentation for Asthma to an Emergency Department in UK (RAPAE)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Asthma Acute. Basic parameters: 16 years — 99 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Retrospective Study Investigating the Clinical Characteristic of Patients with Acute Presentation for Asthma to the A+E Department in a Busy Acute Hospital in England UK in Era of Biological Therapy for Asthma Between Jan 2019 & Jan 2024
Overview
Study team will obtain a list of all patients who have been seen in A+E over the past 6 years with a discharge diagnosis of asthma. Their history will be reviewed from their A+E notes. Team will obtain weight and height from Electronic prescribing tool and will obtain compliance information and past medical history from participant's GP records. Team will use participant's postcode to word out socio economic status quintile using office of national statistics tool. The following information will be taken from hospital documentation and from GP records.
Detailed description
1. How many previous admissions in past one year (12 months) 2. How many presentations to A+E in previous one year (12 months) 3. Diagnosis not confirmed therefore not on any ICS 4. Poor compliance (less than 75% of ICS and/or LABA and/or LAMA and/or leukotriene prescriptions picked up in past year) 5. Recent presentation and maintenance therapy not increased (primary care or secondary care issue) 6. Is patient overweight BMI 7. Is patient on hormonal therapy, OCP, HRT, male hormones 8. Social class quintile from post code of address using ONS calculator 9. Ethnically diverse (see appendix) 10. First Eosinophil count on index admission 11. Highest eosinophil count in past (ever) and date 12. Treatment for diabetes type 2 13. Treatment for diabetes type 1 14. Treatment for hypertension 15. Smoker ever (pack year) when gave up\_\_\_\_\_\_\_\_\_\_
After obtaining this information study team will use simple statistical methods such as frequency and associations with confidence intervals to investigate which factors are associated with frequency of presentation to A+E. They will ascertain the frequency of patients who are on maximum therapy and may benefit from biological therapy, especially if they have raised eosinophils in the past year.
Primary outcome measures
- Change in body weight [Time frame: 5 years]
- Change in body height [Time frame: 5 years]
Eligibility criteria
Inclusion criteria
- All Asthmatics patients who attend Emergency department over 5 years
Exclusion criteria
- None Asthmatics.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06360185 · Asthma V2 October 2023