Natural Course and Therapeutic Effect of Recurrent Acute Pancreatitis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: endoscopic intervention, surgery or conservative treatment.
- Who it may be relevant to
- Registry conditions: Cohort Study, Recurrent Acute Pancreatitis. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Natural Course and Therapeutic Effect of Recurrent Acute Pancreatitis: a Prospective Cohort Study
Overview
The goal of this observational cohort study is to learn about the etiology, natural course, therapeutic effect and outcome of recurrent acute pancreatitis patients. The main question it aims to answer is: Does endoscopic intervention, surgery or conservative treatment reduce the recurrence of acute pancreatitis? What are the risk factors affecting the recurrence of acute pancreatitis? Patients will be closely followed and clinical information will be recorded.
Detailed description
Acute pancreatitis is one of the most common causes of acute hospital admission, which is unpredictable and contributes to high health-care costs even death. Recurrent acute pancreatitis is defined as two or more discrete episodes of acute pancreatitis, and has an estimated annual incidence of 8-10 per 100 000. Cholelithiasis, alcohol and Hyperglyceremia are the most commonly recognized causes of acute pancreatitis. About 80% of RAP patients can be identified through routine investigations identify (include proper history, physical examination, CT, MRI, endoscopic ultrasound); however, in up to 20% of cases whose cause remains unclear are known as idiopathic RAP. For RAP patients with clear cause, removal of the cause can effectively reduce or prevent recurrence. For patients with idiopathic RAP, the treatment options are not clear and have been subject to debate. At present, the natural course, outcome and therapeutic effect of RAP is still not clear. Therefore, the prospective cohort can clarify the clinical characteristics of RAP more comprehensively and deeply and to accumulate evidence for treatment.
Interventions
- Combination product endoscopic intervention, surgery or conservative treatment
Personal information and treatment of the enrolled subjects will be collected.
Primary outcome measures
- Recurrence rate of acute pancreatitis [Time frame: Through study completion, an average of 1 year]
Secondary outcome measures (6)
- Proportion of patients with different treatment [Time frame: Through study completion, an average of 1 year]
- Characteristics of acute pancreatitis [Time frame: Through study completion, an average of 1 year]
- Proportion of patients wtih pain in RAP patients [Time frame: Through study completion, an average of 3 year]
- Proportion of patients with chronic pancreatitis [Time frame: Through study completion, an average of 3 year]
- Evaluation of quality of life [Time frame: Through study completion, an average of 3 year]
- Evaluation of psychological condition [Time frame: Through study completion, an average of 3 year]
Eligibility criteria
Inclusion criteria
- Patients with recurrent acute pancreatitis.
Exclusion criteria
- Unwilling or unable to provide consent.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Changhai Hospital — Shanghai
Identifiers
NCT: NCT06355206 · NACRE20230306