Effect of Anti-inflammatory Diet in Patients With Inflammatory Bowel Disease

Official title

Effects of Anti-inflammatory Diet on Inflammatory Markers, Anxiety, Depression and Quality of Life in Patients With Inflammatory Bowel Disease

Overview

For the first time, this study developed an anti-inflammatory diet （AID） recipe suitable for Inflammatory bowel disease（IBD） patients and developed an AID application program to verify the intervention effect of AID on IBD patients, which not only promoted the application of AID in IBD patients and promoted the promotion of AID model, but also provided new ideas for the prevention and treatment strategies for IBD patients.

Detailed description

This study aims to verify the intervention effect of AID on IBD patients, promote the promotion of AID model, and provide new ideas for the prevention and treatment strategies of IBD patients.

In this study, 66 IBD patients who met the inclusion criteria were divided into experimental group and control group by randomized controlled trial method. The experimental group was based on routine nursing measures, and the intervention group taught patients to take anti-inflammatory diet and use the anti-inflammatory diet mini-program developed by the researcher, daily anti-inflammatory diet, intervention time was 8 weeks, and observed the inflammatory indicators (white blood cells, neutrophils, erythrocyte precipitation, CRP), quality of life, anxiety and depression, self-efficacy and other conditions in the blood results of the patients before and after intervention.

Interventions

• Behavioral Anti-inflammatory diet group
  Patients in the intervention group were given AID knowledge education, and patients were asked to pay attention to the "anti-inflammatory diet" wechat mini program developed by the researchers to teach patients how to use it, including the selection of anti-inflammatory diet, unsuitable anti-inflammatory diet, diet alarm clock, diet notes and other related functions. The missionary patients insisted on AID until reexamination 8 weeks later.

Primary outcome measures

• C-reactive protein [Time frame: 8 weeks after intervention]
• Erythrocyte sedimentation rate (ESR) [Time frame: 8 weeks after intervention]
• Leukocyte [Time frame: 8 weeks after intervention]

Secondary outcome measures (5)

• Self-Rating Anxiety Scale，SAS [Time frame: 8 weeks after intervention]
• Self-Rating depression scale，SDS [Time frame: 8 weeks after intervention]
• Simplified Chinese version of Inflammatory Bowel Disease Quality of Life Scale (IBDQ) [Time frame: 8 weeks after intervention]
• Inflammatory Bowel Disease Self-Efficacy Scale (IBD-SES) [Time frame: 8 weeks after intervention]
• Body Mass Index [Time frame: 8 weeks after intervention]

Eligibility criteria

Inclusion criteria

• Diagnosis of inflammatory bowel disease, the diagnostic criteria refer to the 2018 revised Consensus opinion on the diagnosis and treatment of inflammatory bowel disease;
• The patient has clear consciousness and certain understanding, language expression and writing ability;
• Patients participated in this study knowingly and voluntarily;
• At least 18 years old.

Exclusion criteria

• cognitive impairment, mental illness, accompanied by mental disorders;
• Alcohol and drug abusers.
• The patient could not participate in the researcher due to the deterioration of the condition;
• Patients who voluntarily quit due to other reasons;
• Those who did not complete the assessment scale during the experiment.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation

Randomized

Model

Parallel assignment

Masking

Double blind

Primary purpose

Other

Study locations

China · 1 center

• The Fourth Affiliated Hospital of Zhejiang University School of Medicine — Yiwu

Identifiers

NCT: NCT06342011 · KY-2024-039

Primary sources (government registries)

• ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗