The Application of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Renal microcirculation quantitatively assessed by Contrast-enhanced ultrasound.
- Who it may be relevant to
- Registry conditions: Intensive Care Unit, Acute Kidney Injury, Ultrasound. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Application of Contrast-enhanced Ultrasound in Acute Kidney Injury in Intensive Care Unit
Overview
The goal of this study is to quantitatively assess renal microcirculation changes by contrast-enhanced ultrasound and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore its predictive value in renal function recovery in patients with critical acute kidney injury. The main questions it aims to answer are: 1. To explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation. 2. To explore the relationship between renal microcirculation and systemic hemodynamics. 3. To explore the value of renal microflow changes quantitatively evaluated by contrast-enhanced ultrasound in predicting renal function recovery.
Detailed description
Quantitative analysis of cortical perfusion by contrast-enhanced ultrasound； Echocardiography； Quantitative results of renal artery and vein spectrum
Interventions
- Other Renal microcirculation quantitatively assessed by Contrast-enhanced ultrasound
Renal microcirculation quantitatively assessed by Contrast-enhanced ultrasound before hospital discharge
Primary outcome measures
- Serum creatinine values and/or urine output [Time frame: Through study completion, an average of 7 days]
Eligibility criteria
Inclusion criteria
- Age >18 years old;
- AKI was diagnosed < 24 hours after first admission to intensive care unit (ICU) and the expected length of stay in ICU ≥48 hours;
- Meet Kidney Disease Improving Global Outcomes (KDIGO) 2012 diagnostic criteria for acute kidney injury;
- Contrast-enhanced ultrasound was performed within 24 hours after diagnosis of acute kidney injury (AKI).
Exclusion criteria
- Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment;
- Kidney transplantation or renal malignancy;
- Terminal stage of malignant tumor;
- Pregnancy;
- Renal artery stenosis or renal vein thrombosis;
- Allergy to contrast agent SonoVue(BraccoSpA, Milan, Italy) or its components, or the presence of severe cardiopulmonary insufficiency (e.g., right-to-left shunt heart disease or pulmonary systolic blood pressure >90mmHg).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Department of Ultrasound Diagnosis, Peking University Third Hospital — Beijing
Identifiers
NCT: NCT06341062 · M2024078