Familial Form of Carotid Web: a Doppler Ultrasound Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Doppler ultrasound.
- Who it may be relevant to
- Registry conditions: Carotid Web. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Family Screening for Internal Carotid Diaphragm Dysplasia (Carotid WEB): a Doppler Ultrasound Study
Overview
There is no evidence of familial forms of carotid web. The aim of this study is to determine the prevalence of carotid web among relatives of patient with carotid web using carotid doppler ultrasound.
Detailed description
Carotid web are rare, focal dysplasia of the internal carotid artery and a high risk causes of stroke in young adult. Natural history of these dysplasia remains poorly understood. High prevalence of carotid web among Afro-Caribbean population and the similarity between carotid web and fibromuscular dysplasia, suggest existence of genetic factors. But there has been to our knowledge no familial form of carotid web reported. The aim of this study is to determine the prevalence of carotid web among relatives of patients with carotid web using carotid duplex doppler ultrasound.
Researchers aim to test whether carotid web could be detected in relatives of patients with known carotid web, using duplex doppler ultrasound.
This is a pilot, transversal, single-center study performed at Toulouse University Hospital, France. From 30 carotid web cases aged under 65 (patients with previously known Carotid web, symptomatic or not) followed in neurology department, investigators aim to include 60 first-degree relatives younger than 65 years old. Included relatives will underwent carotid duplex doppler ultrasound to detect carotid web. The primary outcome is the prevalence of carotid web among relatives. Secondary outcomes include : Number of families with at least one relative who has been diagnosed with carotid web, number of relatives who has been diagnosed with carotid web per family, clinical characteristics of patients and morphological characteristics of carotid web.
Interventions
- Procedure Doppler ultrasound
Participants will receive doppler ultrasound of the carotid arteries, and no other interventions studied
Primary outcome measures
- Evaluation of the prevalence of carotid web by doppler ultrasound in first-degree relatives of patients with carotid web. [Time frame: Inclusion day]
Secondary outcome measures (2)
- Description of the clinical characteristics of relatives with carotid web and their index case. [Time frame: Inclusion day]
- Description of the morphological characteristics of relatives with carotid web and their index case. [Time frame: Inclusion day]
Eligibility criteria
Inclusion criteria
Carotid Web index patients:
- Patients with carotid web confirmed by CT angiogram (CTA) of cervical arteries or digital substraction angiogram (DSA).
- At least one first degree relative aged younger than 65 years old.
Relatives patients :
\- First degree relatives of patient with diagnosed carotid web.
Exclusion criteria
- Persons placed under judicial protection or under another protection status
- Pregnant or breastfeeding woman.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Screening
Study locations
France · 1 center
- CHU de Toulouse, Purpan — Toulouse
Identifiers
NCT: NCT06336083 · RC31/23/0618