Minimally Invasive Treatments of the Thyroid
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: image-guided thermal ablation.
- Who it may be relevant to
- Registry conditions: Papillary Thyroid Microcarcinoma. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Multicenter International Prospective Analysis on Minimally Invasive Treatments of the Thyroid (MIPA- MITT) of of Micropapillary Thyroid Carcinoma
Overview
This is a prospective cohort study to test Minimally Invasive Treatments of the Thyroid (MITT) as potential alternative to surgery in patients with Papillary Thyroid MicroCarcinoma (PTMC)
Detailed description
Image-guided thermal ablations have been successfully applied in the treatment of several type of tumors, and have been recently proposed as a potential alternative to surgery also in patients with thyroid diseases, and named "Minimally Invasive Treatments of the Thyroid (MITT)". These minimally invasive treatments, compared to surgical treatment have similar efficacy, fewer complications, better quality of life, and better cosmetic outcomes. These procedures allow precise delivery of the heat locally to the lesion, sparing the surrounding thyroid tissue, and thus minimizing the invasiveness of the treatment and the impact on thyroid function.
This study aim to establish a prospective registry of the cases of patients treated with MITT for a Papillary Thyroid MicroCarcinoma (PTMC), in order to validate the safety of the procedure and to set the basis for collecting long term results in a large cohort of patients.
Interventions
- Procedure image-guided thermal ablation
image-guided thermal ablation in patients with diagnosis of micropapillary thyroid carcinoma
Primary outcome measures
- The proportion of patients with major complications occurring within one month after the date of intervention [Time frame: 1 month]
Secondary outcome measures (3)
- Percentage of patients with local recurrence at 10 years [Time frame: 10 years]
- Percentage of patients with distant metastasis at 10 years [Time frame: 10 years]
- Percentage of patients died at 10 years [Time frame: 10 years]
Eligibility criteria
Inclusion criteria
- Patients > 18years
- Patients with diagnosis of papillary thyroid microcarcinoma, citologically proven, suitable for MITT.
- Written informed consent must be signed and dated by the patient and the investigator prior to inclusion.
- Patients must be accessible for follow-up
Exclusion criteria
- Tumors > 1 cm, other citological type, refusal of MITT, unsuitable for MITT, unmanageable coagulative disorders
- Patients with psychiatric, addictive, or any disorder, which compromises ability to give informed consent for participation in this study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
Italy · 1 center
- European Institute of Oncology — Milan
Identifiers
NCT: NCT06333587 · IEO 1810