Translational Initiative to Map Epigenetics in Sleep
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Surveys.
- Who it may be relevant to
- Registry conditions: Biological Aging. Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The primary aim of TIME-ZZZ is to explore the relationship between chronotype, incidence of depression and biological age, and whether individuals working "out-of-phase" with their chronotype are more likely to exhibit signs of depression and accelerated biological aging.
Detailed description
Understanding the relationship between chronotype, depression, and biological age is important in the field of sleep research and mental health. Sleep patterns and their alignment with an individual's internal body clock, or chronotype, have been increasingly recognized as influential factors in various aspects of well-being, including mental health and overall physiological aging. By conducting a study that investigates the potential correlation between chronotype, incidence of depression, and biological age, along with the impact of working "out-of-phase" with one's chronotype, the investigators can shed light on crucial aspects of sleep, mental health, and their interplay with biological aging.
Interventions
- Other Surveys
Group will complete several surveys
Primary outcome measures
- Effect of being "out of phase" with chronotype on biological age [Time frame: At baseline]
Secondary outcome measures (3)
- Effect of Chronotype Alignment and Depression Risk in Relation to Rate of Aging [Time frame: At baseline]
- Identification of DNA methylation markers associated with chronotype [Time frame: At baseline]
- Identification of DNA methylation markers associated with depression [Time frame: At baseline]
Eligibility criteria
Inclusion criteria
- Has taken an INDEX test within the last 3 months
- Has registered at least 1 INDEX kit via the Elysium Health website
- Able and willing to provide digital consent to the RSCF, and the TIME-ZZZ Research Subject Consent Form
Exclusion criteria
- Consent to participate not given
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06333301 · TIME-ZZZ