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Recruiting NCT06331377

Clinical and Molecular Characteristics of Histiocytic Disorders

— Observational Histiocytic Disorder

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Non-Interventional Study.
Who it may be relevant to
Registry conditions: Histiocytic Disorder. Basic parameters: from 1 year · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

This study is being done to collect medical and personal histories as well as a samples of blood, other body fluid and/or tumor/disease tissue for current and future research studies on histiocytic disorders.

Detailed description

PRIMARY OBJECTIVES:

I. Define molecular signature and genomic landscape of histiocytic disorders. II. Correlate genomic findings with transcriptional abnormalities. III. Identify promising prognostic alterations and potential therapeutic targets.

OUTLINE: This is an observational study.

Patients complete questionnaires and undergo blood and tissue sample collection. Patients' medical records are also reviewed.

Interventions

  • Other Non-Interventional Study
    Non-interventional study

Primary outcome measures

  • Identify molecular markers [Time frame: Baseline]
  • Change in PD-L1 and T-cell Bim expression [Time frame: Baseline; post-treatment (estimated up to 2 years, potentially 4 times per year)]

Eligibility criteria

Inclusion criteria

  • All patients diagnosed with histiocytic disorders and age ≥1 year

Exclusion criteria

  • < 1 years age

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Case-only

Study locations

United States · 1 center
  • Mayo Clinic in Rochester — Rochester

Identifiers

NCT: NCT06331377 · 17-004541 · NCI-2024-01765 · 17-004541

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗