Age-related Conditions in the Context of Multimorbidity and Frailty: Relative Weight of Frailty in Determining the Course and Outcomes of Different Chronic Diseases and Viceversa
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: completion of scales and questionnaires; venous blood sampling; muscle ultrasound; cardiac ultrasound; electrocardiogram; bioelectrical impedance analysis.
- Who it may be relevant to
- Registry conditions: Frailty, Sarcopenia. Basic parameters: 18 years — 100 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Observational study. Participants of the FRASNET study (9th March 2017, Protocol No. 24/INT/2017) who were evaluated in 2016 and 2017 will be contacted to be re-evaluated with multidimensional visits as part of the present study in order to assess trajectories and biomarkers of frailty and sarcopenia. Moreover, are going to evaluate with the same multidimensional visits patients with mild cognitive impairment and dementia followed up at the Neurologic Unit of the San Raffaele Hospital.
Interventions
- Diagnostic test completion of scales and questionnaires; venous blood sampling; muscle ultrasound; cardiac ultrasound; electrocardiogram; bioelectrical impedance analysis
The sub-investigator performs a multidimentional geriatric evaluation
Primary outcome measures
- identify new molecular markers of frailty and sarcopenia [Time frame: febbrary 2026]
Secondary outcome measures (1)
- evaluate the ability of new markers for frailty, sarcopenia, cognitive impairment [Time frame: april 2026]
Eligibility criteria
Inclusion criteria
- Having participated in the FRASNET study or being a patient with mild cognitive impairment or dementia followed up at the Neurologic Unit of the San Raffaele Hospital
- Ability to sign written informed consent
- > 18 years old
Exclusion criteria
- Life expectancy < 6 months
- Unwillingness to participate in the study
- Unstable clinical disease(for ex. serious acute pathologies)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
Italy · 1 center
- San Raffaele Hospital — Milan
Identifiers
NCT: NCT06324149 · AGE-IT-FRAILTY