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Recruiting NCT06318767

Predictive Value of Systolic Rise Time of the Plantar Arch on the Risk of Major Adverse Limb Events (MALE) and Major Adverse Cardiovascular Events (MACE) in Peripheral Artery Disease (PAD) at Critical Ischaemia Stage

No phase Interventional Major Adverse Limb Events Major Adverse Cardiovascular Events Peripheral Artery Disease Critical Limb Ischemia

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: hemodynamic measure of the Systolic Time Rise.
Who it may be relevant to
Registry conditions: Major Adverse Limb Events, Major Adverse Cardiovascular Events, Peripheral Artery Disease, Critical Limb Ischemia. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
France
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

Peripheral artery disease (PAD), vascular disease of atheromatous origin, is a frequent pathology, with a steady and significant increase in prevalence over the last decades. It has various symptoms ranging from mild arterial claudication to critical limb ischemia. The critical ischaemia stage in PAD is defined by rest pain or trophic disorders and is a special situation because of the number of cardiovascular deaths at 1 year (25%), 60% at 5 years and acute ischaemic recurrence at 1 year (25%). It is a medico-surgical pathology. A haemodynamic marker is needed to monitor patients, as it is predictive of limb progression, cardiovascular events and mortality. The Systolic Rise Time (SRT) of the plantar footpad is a recently described haemodynamic measurement of proven value in the diagnosis of PAD. The aim of this study is to show the prognostic value of the Systolic Rise Time on Major Adverse Limb Events (MALE).

Interventions

  • Other hemodynamic measure of the Systolic Time Rise
    The hemodynamic measure of the Systolic Time Rise will be added in the routine doppler echography, planned in preoperative, postoperative and at 6 months of following up. This measure is taken on the foot, with ultrasound probe.

Primary outcome measures

  • occurrence of limb ischemia [Time frame: 6 months]

Eligibility criteria

Inclusion criteria

  • patients at least 18 years old,
  • willing and able to provide written informed consent,
  • with documented atherosclerosis critical limb ischemia (pain rest and/or ulcer and gangrene manifestations)
  • with hemodynamic measures (ankle pressure less than 50mmHg and/or TBI less than 30mmHg and/or TcPO2 less than 30 mmHg),
  • followed or send to CHU Amiens Picardie, and eligible to chirurgical revascularization.

Exclusion criteria

  • with non atherosclerosis arteriopathy,
  • ineligible to the gold standard treatment such as the chirurgical revascularization,
  • with life expectancy less than 3 months.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Diagnostic

Study locations

France · 1 center
  • CHU Amiens — Amiens

Identifiers

NCT: NCT06318767 · PI2023_843_0141

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗