Thyroid and Cortisol Hormone Response to Sepsis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Sepsis. Basic parameters: 18 years — 100 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Thyroid and Cortisol Hormone Response in Patients With Sepsis Who Attended To Assiut University Hospitals (ICU)
Overview
Thyroid and cortisol hormone response to sepsis
Detailed description
Sepsis is dysregulated host response to infection that results in life-threatening organ dysfunction. Virtually every body system can be affected by this syndrome to greater or lesser extents.
Endocrine alterations are well characterised in sepsis with variations in circulating blood levels and/or receptor resistance.
In response to any psychological or physical stressor, there is widespread neurohormonal activation to adapt body with the stressor. Production and secretion of stress hormones increase to modulate behaviour Many studies have been performed investigating specific hormonal perturbations such as critical illness-induced corticosteroid insufficiency ,all of which are associated with worse outcomes and poor of body inflammation. However, the endocrine system as a whole has been largely overlooked as a fundamental contributor to the integrated host response to sepsis thyroid axis is affected during sepsis with decreased pituitary release of thyroid stimulating hormone (TSH) and inhibition of the peripheral conversion of thyroxine (T4) by 5-deiodinase to the much more metabolically active triiodothyronine (T3). High cortisol levels also inhibit this enzymatic conversion.
Primary outcome measures
- Pattern of cortisol level and thyroid function response to sepsis in ICU [Time frame: From time of admission to ICU up to 3rd day after discharge]
Eligibility criteria
Inclusion criteria
- The study will include Adults (≥18 years), both genders
- septic patients admitted to critical care unit
Exclusion criteria
- thyroid disease
- hypopituitarism
- Addison disease
- Cushing syndrome)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Publications
- Silva MH, Araujo MC, Diniz EM, Ceccon ME, Carvalho WB. Thyroid abnormalities in term infants with fungal sepsis. Rev Assoc Med Bras (1992). 2016 Sep;62(6):561-567. doi: 10.1590/1806-9282.62.06.561. PMID 27849234
Identifiers
NCT: NCT06289179 · Thyroid and cortisol in sepsis