YOD-RiSoCo: Social Cognition and Risk-taking Behaviour in Patients with Young-onset Dementia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Neuropsychological assessment, driving simulator task.
- Who it may be relevant to
- Registry conditions: Young-onset Dementia. Basic parameters: 18 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
YOD-RiSoCo: the Role of Social Cognition and Better Identification of Risk-taking Behaviour in Patients with Young-onset Dementia
Overview
The goal of this observational study is to learn about social cognition and risky behaviour in patients with young-onset dementia (YOD). The investigators want to * Examine differences in performance on social cognition test and measures of risky behaviour between behavioural variant YOD patients, patients with frontal brain injury, non-behavioural YOD patients and healthy controls. * Examine if there is a relation between social cognition tests and measures of risky behaviour. Participants will be administered a neuropsychological assessment including social cognition measures and patients will complete a driving simulator task in which risky behaviour will be elicited.
Interventions
- Other Neuropsychological assessment, driving simulator task
Neuropsychological assessment consisting of test measuring general cognitive abilities and social cognition. Driving simulator task measuring risk-taking.
Primary outcome measures
- Social cognitive performance [Time frame: 2024-2027]
Secondary outcome measures (1)
- Association between social cognition and risky decision-making [Time frame: 2024-2027]
Eligibility criteria
Inclusion criteria
All subjects
- Sufficient command of the Dutch language
- In possession of a driver's license with any driving experience throughout life
- Age 18 to 65
bvYOD subjects
- Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG/PIB-PETscans, CSF biomarkers or genetic counseling were discussed.
- Nosological diagnosis of bvFTD or bvAD
Non-bvYOD subjects
- Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG/PIB-PETscans, CSF biomarkers or genetic counseling were discussed.
- YOD subtypes other dan bvFTD or bvAD, such as amnestic variant AD.
Frontal brain injury subjects
\- Neurological patients with frontal brain injury (e.g. traumatic brain injury, stroke or brain tumor patients).
Exclusion criteria
All subjects
- Suffering from severe motion sickness; motion sickness is a risk factor for simulator sickness
YOD subjects:
\- Presence of premorbid severe neurological or psychiatric pathology, non-related to dementia.
Frontal brain injury subjects:
\- Presence of serious psychiatric disorders or other neurological comorbidities.
Healthy control subjects:
- Presence of serious psychiatric disorders
- History of neurological disorders, which may interfere with cognitive functioning (e.g. recent concussion, previous subarachnoid or intracerebral haemorrhage, intracranial tumours, epilepsy, ischemic stroke).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
Center list to be confirmed — check the primary protocol.
Publications
- Gelmers F, Huitema RB, Scheenen ME, van Munster BC, Spikman JM; YOD-INCLUDED Consortium. Assessing social cognition and risk-taking behaviour in patients with young-onset dementia: Study protocol for the YOD-RiSoCo observational prospective cohort study. PLoS One. 2025 May 27;20(5):e0324517. doi: 10.1371/journal.pone.0324517. eCollection 2025. PMID 40424326
Identifiers
NCT: NCT06286293 · 18171