Study of Brain-spinal Cord Neural Connectivity in Spasticity
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: intraoperative neuroelectrophysiological monitoring.
- Who it may be relevant to
- Registry conditions: Spasticity, Muscle. Basic parameters: 3 years — 17 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Little is known about the peripheral and central mechanisms of action of selective dorsal rhizotomy surgery for the treatment of spasticity. A better understanding of these mechanisms will enable us to improve the surgical procedure. This will require cortico-medullo-radiculo-muscular recordings never before performed and published in the literature, and the identification of variations in connectivity correlated with the clinic.
Interventions
- Other intraoperative neuroelectrophysiological monitoring
The procedure involves intraoperative neuroelectrophysiological monitoring. The aim is to record the electrical activity of the central and peripheral nervous system at several levels during a neurosurgical procedure. The equipment used comes from INOMED and consists of : * a recording station (ISIS) * scalp corkscrew electrodes (2 to 4 electrodes) * a 4-pin FSR spinal cord electrode (Ad-Tech) * hook electrodes for roots/radicles (X2) * needle electrodes for muscles (X18) Electrode placement
Primary outcome measures
- variation in "spontaneous/resting" cortico-medullo-radiculo-muscular synchronization before and after selective rhizotomy surgery [Time frame: Day 0]
Eligibility criteria
Inclusion criteria
- Patients aged 3 to 17 years included
- scheduled for selective rhizotomy surgery
- Having received informed consent to participate in the study (written consent from both parents)
- Affiliated or beneficiary of a social security scheme
Exclusion criteria
- Contraindications to selective rhizotomy
- History of epilepsy
- Known neurological and/or psychiatric disorders with past and/or current medical treatment, or drug addiction
- Patient under legal protection
- Pregnant or breast-feeding women
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
France · 2 centers
- Hpu Lenval — Nice
- HFAR — Paris
Identifiers
NCT: NCT06281223 · JBR_2023_9