Adrenal Project: Clinical and Epidemiological Characterization of Adrenocortical Carcinoma in a Brazilian Cohort
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Carcinoma Adrenal, Carcinoma, Adrenocortical Recurrent. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Brazil
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This is a retrospective observational cohort study. The clinical, pathological and treatment data of participants identified with adrenocortical carcinoma from the year 2000 onwards will be evaluated. Participants recruited for this study will be identified at the participating sites.
Detailed description
Adrenocortical carcinoma is one of the rarest neoplasms in the world. In Brazil, especially in the South and Southeast regions, the incidence of adrenocortical tumors is around 15 times higher than in the rest of the world, largely attributed to the significant prevalence of the TP53-R337H germline mutation in this population. In view of this characteristic, the clinical and epidemiological characterization of this cohort, as well as the identification of prognostic factors, is of great importance. The starting point for this project was the cohort of 66 participants with adrenal carcinoma included in the final project of the medical residency in clinical oncology at the A.C. Camargo Cancer Center by student Rafael Haikal dos Santos Abduch. The aim is to include case studies from the main Brazilian site that have followed up and treated patients with adrenal carcinoma.
Primary outcome measures
- Demographic Characterization of Adrenocortical Carcinoma in Brazil [Time frame: Throughout the study period, an average of 18 months.]
- Clinical Characterization of Adrenocortical Carcinoma in Brazil [Time frame: Throughout the study period, an average of 18 months.]
Eligibility criteria
Inclusion criteria
- Participants over 18 years old;
- Diagnosis of adrenocortical carcinoma with at least one clinical evaluation at the reference institution;
- Initial diagnosis or recurrence from the year 2000 onwards.
Exclusion criteria
- Participants with insufficient clinical or pathological data in the medical records.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Brazil · 10 centers
- Pronutrir - Suporte Nutricional e Quimioterapia — Fortaleza
- Hospital do Câncer do Maranhão Dr. Tarquínio Lopes Filho — São Luís
- Hospital Erasto Gaertner — Curitiba
- Hospital Santa Joana Recife (Instituto Américas PE) — Recife
- UOPECCAN - Hospital do Câncer de Cascavel — Cascavel
- FUNFARME - Hospital de Base de São José do Rio Preto — São José do Rio Preto
- INCA - Instituto Nacional de Câncer — Rio de Janeiro
- BP - A Beneficência Portuguesa de São Paulo — São Paulo
- … and 2 more centers
Identifiers
NCT: NCT06279442 · LACOG 0723