Protein Molecular Characteristics and Prognosis of Cervical Neuroendocrine Tumors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Neuroendocrine Neoplasm, China, Women, Cervical Cancer. Basic parameters: No limits · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were collected, including age, preoperative biopsy pathology results, postoperative histopathological results, TCT results, and colposcopy biopsy pathology results. At the same time, paraffin tissue specimens (remaining specimens after pathological diagnosis) from 100 cases of cervical neuroendocrine tumors from multiple centers across the country were collected to establish a cervical neuroendocrine tumor data follow-up database. Protein concentration and omics analysis were performed on the data results, to evaluate the molecular characteristics and prognosis of cervical neuroendocrine tumor proteins, and to preliminarily explore its clinical application value.
Detailed description
1\. The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were used for prognostic analysis.
(1) The diagnosis and treatment information of cervical neuroendocrine carcinoma in multiple hospitals was collected, including clinical and medical data such as age, preoperative HPV genotyping, preoperative biopsy pathological results, postoperative histopathological results, FIGO staging, prognosis and survival information, and follow-up of patients.
2\. Protein and other omics analysis was performed on paraffin tissues of 100 cases of cervical neuroendocrine tumors Paraffin samples collected from 100 cases of cervical neuroendocrine tumors were identified, processed and segmtioned, and protein concentration and proteome were determined to establish the molecular characteristics and prognostic targets of cervical neuroendocrine tumors.
Primary outcome measures
- mortality rate [Time frame: Among patients with cervical neuroendocrine carcinoma, the mortality rate within 3 years following surgery]
- Disease-free survival [Time frame: Among patients with cervical neuroendocrine carcinoma, the disease-free survival within 3 years following surgery]
Eligibility criteria
Inclusion criteria
- Patients diagnosed with cervical neuroendocrine carcinoma by histopathology
- Clinical data were complete
Exclusion criteria
- Patients who are not being treated in our hospital
- Patients with lack of follow-up data, unable to obtain survival information
- Patients call to refuse to participate in this project
- The quality of paraffin specimens can not meet the requirements of proteome concentration determination
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 9 centers
- Fujian Maternity and Child Health Hospital — Fuzhou
- Fujian Provincial Hospital — Fuzhou
- Ningde Mindong Hospital — Ningde
- Putian City first Hospital — Putian
- The Second Affiliated Hospital of Fujian Medical University — Quanzhou
- Zhangzhou affiliated Hospital of Fujian Medical University — Zhangzhou
- Maternal and Child Health Hospital of Hubei Province — Wuhan
- Xiangya Hospital, Central South University — Changsha
- … and 1 more center
Identifiers
NCT: NCT06276309 · NECC2401