Chinese Occupational Population Cohort of Lifestyle and Physical Fitness (LiFitChina)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Lifestyle, Physical Fitness, Cardiovascular Diseases. Basic parameters: 18 years — 59 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Effects of Lifestyle and Physical Fitness on Cardiovascular Health: a Cohort Study in Chinese Occupational Population
Overview
The incidence and prevalence of metabolic risk factors such as obesity, hypertension, diabetes, and dyslipidemia, as well as cardiovascular diseases (CVD), are continuously rising among the occupational population in China, primarily comprising the middle-aged and young adults. Unhealthy lifestyles and declining physical fitness are independent risk factors affecting cardiovascular health. Additionally, the level of physical fitness is influenced by postnatal lifestyles. Lifestyle factors related to cardiovascular health in the occupational population encompass various aspects, including smoking, physical activity, diet, sleep, psychological stress, etc. These factors may interact or have a synergistic effect, necessitating a comprehensive assessment. This project proposes a prospective cohort study design to establish a monitoring cohort for lifestyle and physical fitness among the occupational population. The study will track and follow individuals with or without any CVD metabolic risk factors, collecting information on general status, lifestyle, physical fitness, and health examination data. Exposure factors such as lifestyle and physical fitness will be measured annually, and the occurrence of CVD-related health outcomes will be observed. The aim is to develop a comprehensive evaluation index for cardiovascular health lifestyle, analyze the direct and indirect impacts of lifestyle and physical fitness on the occurrence and development of CVD, and explore potential mediating and moderating effects of physical fitness in the association between lifestyle and cardiovascular health.
Primary outcome measures
- the composite end point of new major adverse cardiovascular events [Time frame: 10 years]
Secondary outcome measures (9)
- new incidence of each major adverse cardiovascular events [Time frame: 10 years]
- new incidence of cancer [Time frame: 10 years]
- new incidence of all-cause death [Time frame: 10 years]
- level of systolic pressure [Time frame: 10 years]
- level of diastolic pressure [Time frame: 10 years]
- level of blood lipid [Time frame: 10 years]
- level of BMI [Time frame: 10 years]
- level of maximal oxygen uptake (VO2max) [Time frame: 10 years]
- level of metabolic equivalents (METs) [Time frame: 10 years]
Eligibility criteria
Inclusion criteria
- adults between 18-59 years of age
- occupational staff
- willing to accept long-term follow-up
Exclusion criteria
- participants with previous CVD history such as myocardial infarction, stroke and severe aortic stenosis;
- with cancer;
- with congenital genetic diseases, or cannot cooperate with the investigation and follow-up due to acquired diseases, such as congenital heart disease, paralysis, deafness, dementia, mental abnormality, developmental retardation, etc.;
- with exercise contraindications;
- duration of pregnancy;
- refuse to sign the informed consent.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sc — Beijing
Identifiers
NCT: NCT06275009 · 2023-1990