Using TMS to Understand Neural Processes of Social Motivation
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: TMS.
- Who it may be relevant to
- Registry conditions: Social Avoidant Behavior, Major Depressive Disorder, Social Anxiety Disorder. Basic parameters: 25 years — 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Personalized Neuromodulation Targeting Dysregulated Motivational Responses Underlying Social Avoidance Behavior
Overview
The purpose of this study is to use transcranial magnetic stimulation (TMS) to better understand the neural circuits associated with social motivation. Participant includes four study visits each that range from 1.5 - 3.0 hours in duration over approximately a one month period. The first study visit involves answering survey questions, a clinical interview, and computer tasks. The second study visit involves a magnetic resonance imaging (MRI) scan, computer tasks, and a brief TMS protocol. The second and third study visits involve a full session of TMS followed by an MRI scan and computer tasks. Adults in the Auburn/Opelika area and surrounding areas who avoid social situations, experience symptoms of depression or social anxiety, and are between 25 years old and 50 years old are eligible to participate.
Interventions
- Device TMS
TMS will be administered using a Cool B-65 coil to a personalized right dlPFC region.
Primary outcome measures
- Social motivation [Time frame: Immediately post-intervention]
- Neural circuit function [Time frame: Immediately post-intervention]
Eligibility criteria
Inclusion criteria
- A diagnosis of Major Depressive Disorder OR a diagnosis of Social Anxiety Disorder (assessed/confirmed at screening visit).
- Scoring above clinical threshold on a measure of social avoidant behavior (assessed/confirmed at phone screen).
Exclusion criteria
- Unstable psychotropic medication regimen (i.e., changes in psychotropic medication or dosage in past 3 months).
- Current or lifetime diagnosis of Bipolar Disorder.
- A diagnosis of substance use disorder within past 12 months.
- A diagnosis of psychotic-spectrum disorder such as Schizophrenia.
- Pregnancy or probable pregnancy.
- Medical illness or medical treatment that would preclude or inhibit study participation.
- Neurological disorder associated with brain damage.
- History of seizures or head trauma with loss of consciousness > 5 minutes.
- Family history of epilepsy or personal epilepsy/seizures
- Ferromagnetic implants or ferrmagnetic objects within body (e.g., pacemaker).
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Double blind
- Primary purpose
- Basic science
Study locations
United States · 1 center
- Auburn University — Auburn
Identifiers
NCT: NCT06274112 · 1K23MH135222