Distinguishing Alcohol Intoxication, Cannabis Intoxication and Co-intoxication Using Electroencephalography (EEG)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Alcohol, Cannabis.
- Who it may be relevant to
- Registry conditions: Cannabis Use, Alcohol Use, Unspecified. Basic parameters: 21 years — 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Developing Predictive Models to Distinguish Alcohol Use, Cannabis Use and Co-use: An Exploration of Electroencephalography (EEG) Metrics and Traditional Intoxication Measures
Overview
This is a randomized, parallel-group study designed to explore the differences between cannabis intoxication, alcohol intoxication and co-intoxication involving both alcohol and cannabis, utilizing electroencephalography (EEG) as well as more traditional intoxication measures such as breath alcohol concentration and balance metrics. If eligible for the study, participants will be randomized to complete one study session in our mobile laboratory, during which they will use either alcohol, cannabis (which will be self-administered, ad libitum) or both alcohol and cannabis.
Interventions
- Other Alcohol
Participants in this condition will receive the standard alcohol dose - Other Cannabis
Participants in this group will self-administer legal-market flower cannabis
Primary outcome measures
- Electroencephalography (EEG) Objective Cognitive Function Measures--Amplitude (microvolts) [Time frame: Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use]
- Electroencephalography (EEG) Objective Cognitive Function Measures--Latency (milliseconds) [Time frame: Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use]
- Standing postural stability [Time frame: Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use]
Eligibility criteria
Inclusion criteria
- 21-50 years old
- Heavy drinkers (consuming more than 4 drinks/day or more than 14 drinks/week for men, or more than 3 drinks/day or more than 7 drinks/week for women)
- Regular users of legal-market flower cannabis (at least 2x/week in past 3 months)
- report simultaneously using alcohol and legal-market flower cannabis at least once per month in the past 3 months
- English speakers.
Exclusion criteria
- Daily tobacco users
- Diagnosed with or seeking treatment for alcohol use disorder (AUD) or other substance use disorder (SUD)
- Females cannot be pregnant, breastfeeding or trying to become pregnant
- Meet criteria for psychotic, bipolar or major depressive disorder with suicidal ideation, or history of these disorders, 5) Current use of psychotropic (except anti-depressants)
- Report illicit drug use in past 60-days or fail drug screen on the day of the study appointment
- Major medical condition contraindicating alcohol and/or cannabis consumption.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Other
Study locations
United States · 1 center
- Colorado State University — Fort Collins
Identifiers
NCT: NCT06259916 · 5061