Inflammatory Bowel Disease Cohort in Nantes
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Collection of biological samples.
- Who it may be relevant to
- Registry conditions: Inflammatory Bowel Diseases. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Cohorte Nantaise de Maladies Inflammatoires Chroniques Intestinales
Overview
The CELESTE cohort will be a three-center prospective cohort associated with the creation of a biobank including Inflammatory Bowel Diseases (IBD) patients with active disease
Detailed description
The CELESTE cohort will be a prospective cohort of IBD patients followed up at Nantes University Hospital, Jules Verne Clinic (Nantes) and/or Confluent Private Hospital (Nantes). The multicentric nature of the cohort including a tertiary referral center and two secondary care centers is a major asset, enabling the enrolment of a broad spectrum of patients, from those naïve to any immunomodulatory treatment to those refractory to multiple biologic therapies.
It will be associated with a multi-omics biobank with the aim of identifying new cellular and molecular signatures of success of the therapeutic strategy at one year.
Interventions
- Other Collection of biological samples
Collection of blood samples and intestinal biopsies during a surgery or colonoscopy for disease relapse
Primary outcome measures
- Proportion of patients who succeed in their therapeutic strategy [Time frame: One year after inclusion]
Eligibility criteria
Inclusion criteria
- Patients over 18 years of age;
- Patients with an established diagnosis of IBD: CD, UC, unclassified IBD or refractory chronic pouchitis;
- Patients with active disease requiring surgery or endoscopy, whether performed at diagnosis or prior to initiation of new therapy;
- Patients who have given written consent to participate in the study and to keep biological samples for research purposes
Exclusion criteria
- Patients refusing to participate in the cohort;
- Patients with chronic inflammatory bowel disease quiescent at inclusion;
- Patients with a contraindication to general anaesthesia;
- Vulnerable patients (under court protection, curators, guardians);
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
France · 3 centers
- CHU de Nantes — Nantes
- Clinique Jules Verne — Nantes
- Hopital Privé du Confluent — Nantes
Identifiers
NCT: NCT06256393 · RC23_0467