Acute Cardiovascular Responses to a Single Exercise Session in Patients With Post-COVID-19 Syndrome
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Exercise session, Control session.
- Who it may be relevant to
- Registry conditions: Post-Acute COVID-19 Syndrome. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Brazil
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Acute Cardiovascular Responses to a Single Exercise Session in Patients With Post-Covid-19 Syndrome
Overview
The objective of the study is to compare the acute cardiorespiratory and perceptual responses to a physical exercise session in those infected by Covid-19 with and without persistent symptoms.
Detailed description
The study will be a crossover carried out in two groups (with and without persistent symptoms of Covid-19). Participants in both groups will undergo a control session and an exercise session and cardiorespiratory and perceptual responses will be obtained before, during and after the sessions. In the exercise session, participants will perform aerobic exercises, strength exercises and muscle stretching, while in the control session participants will remain seated. Blood pressure, heart rate, cardiac autonomic modulation, peripheral oxygen saturation, vascular function and perception of affect will be obtained.
Interventions
- Behavioral Exercise session
Session will included aerobic, resistance and flexibility exercises and will last approximately 45 minutes. The session will begin with aerobic exercises (5 min jumping jacks and 5 min stationary walking). Then, nine strength exercises will be performed for the main muscle groups (3 times of 12 to 15 repetitions, with a 1-minute rest interval) and finally stretching for the main muscle groups - Behavioral Control session
Remain seated for 60 min
Primary outcome measures
- Change in Blood pressure [Time frame: Before and 30 and 50 minutes after the end of the exercise and control interventions]
- Change in Heart rate variability [Time frame: Before and 30 and 50 minutes after the end of the exercise and control interventions]
- Change in flow mediated dilation [Time frame: Before and 30 minutes after the end of the exercise and control interventions]
- Change in peak exhalation flow [Time frame: Before and 5 minutes after the end of the exercise and control interventions]
- Change in oxygen saturation [Time frame: Before, during and 5 minutes after the end of the exercise and control interventions]
Secondary outcome measures (2)
- Change in heart rate [Time frame: Before and continuously during exercise and control interventions]
- Change in affective response [Time frame: Before and every 5 minutes during exercise and control interventions]
Eligibility criteria
Inclusion criteria
Post-Covid Syndrome group:
- have had a positive RT-PCR test for Covid-19;
- present persistent symptoms of Post Covid 19 syndrome, which have no other health explanation according to the criteria of the World Health Organization (WHO);
- have the cognitive and physical capacity to perform the exercises; It is
- low cardiovascular risk classification according to the American College of Sports Medicine criteria.
Healthy group:
- not present persistent symptoms of Post Covid 19 syndrome, which have no other health explanation according to the criteria of the World Health Organization (WHO);
- have the cognitive and physical capacity to perform the exercises; It is
- low cardiovascular risk classification according to the American College of Sports Medicine criteria.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Brazil · 1 center
- Universidade Nove de Julho — São Paulo
Identifiers
NCT: NCT06248151 · Acute_Covid · 0057/2022