Identification of Prognostic Factors and Role of Radiotherapy in Patients With Ewing Sarcoma
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: clinical records review.
- Who it may be relevant to
- Registry conditions: Ewing Sarcoma. Basic parameters: from 2 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
assess whether there is a correlation between some factors (age, sex, tumor volume, tumor site, chemotherapy-induced necrosis, radiation and biomarkers) and overall survival (OS) and relapse-free survival (RFS) in patients with Ewing sarcoma. Identification of reliable prognostic factors could help to identify high-risk patients, which may require a different treatment and follow up.
Interventions
- Other clinical records review
review the medical records, radiological imaging, and histological data of these patients
Primary outcome measures
- Correlation [Time frame: At baseline (Day 0)]
Eligibility criteria
Inclusion criteria
- Male and female patients treated at Rizzoli Orthopaedic Institute between 01/01/1991 and 31/12/2021
- Age ≥ 2 years
- Diagnosis of Ewing Sarcoma
- Patients with available clinical and imaging data
Exclusion criteria
- At least one inclusion criterion not met
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Italy · 1 center
- IRCCS Itituto Ortopedico Rizzoli — Bologna
Publications
- Grunewald TGP, Cidre-Aranaz F, Surdez D, Tomazou EM, de Alava E, Kovar H, Sorensen PH, Delattre O, Dirksen U. Ewing sarcoma. Nat Rev Dis Primers. 2018 Jul 5;4(1):5. doi: 10.1038/s41572-018-0003-x. PMID 29977059
- Pressman BD, Tourje EJ, Thompson JR. An early CT sign of ischemic infarction: increased density in a cerebral artery. AJR Am J Roentgenol. 1987 Sep;149(3):583-6. doi: 10.2214/ajr.149.3.583. PMID 3497548
Identifiers
NCT: NCT06243588 · ProEwing