Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults.
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Cognition Disorders in Old Age, Cognitive Decline, Cognitive Impairment, Cognitive Dysfunction. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Macau
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Establishing Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults
Overview
The current project is dedicated to creating a comprehensive cognitive and neural assessment platform and corresponding norms tailored specifically to the older adults in Macau.
Detailed description
The investigators will establish this assessment platform using a combination of methods, including interviews, surveys, and expert reviews.
Steps include adapting existing assessment methods to the Macau context, developing new cognitive and neural tasks, defining standardized procedures, seeking external expert input, conducting pilot tests, and validation processes, and refining both the platform and its accompanying manual.
Primary outcome measures
- Normative Data for the Montreal Cognitive Assessment - Chinese (Hong Kong) version [Time frame: From February 2024 to January 2026]
- Normative Data for the Mini-Mental State Examination (MMSE) [Time frame: From February 2024 to January 2026]
- Normative Scores for Computerized Neuropsychological Tasks [Time frame: From February 2024 to January 2026]
Secondary outcome measures (3)
- Neural Activation Patterns During Cognitive Tasks as Revealed by Functional Magnetic Resonance Imaging (fMRI) [Time frame: From February 2024 to January 2026]
- Cerebral Hemodynamics Assessed Through Functional Near-Infrared Spectroscopy (fNIRS) [Time frame: From February 2024 to January 2026]
- Electrophysiological Correlates of Cognitive Activity as Measured by Electroencephalography (EEG) [Time frame: From February 2024 to January 2026]
Eligibility criteria
Inclusion criteria
- Must be a local adult resident of Macau
- Age above 50 years for older adult cohort
- Younger adults individuals above 18 will be included as control comparators
Exclusion criteria
- History of neurological injury or disease
- Current use of medications that affect brain function or blood flow
- Contraindications to MRI scanning, such as the presence of an electric/mechanical implant or device (e.g., pacemaker)
- Claustrophobia
- Body weight over 300 lbs due to weight and physical constraints of the scanner (i.e., bore size limited to 55 cm)
- Inability to provide informed consent
- Pregnancy
- Being under the legal age of adulthood (children)
- Incarcerated individuals (prisoners)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Ecologic or community
Study locations
Macau · 1 center
- Centre for Cognitive and Brain Sciences of the University of Macau — Macao
Identifiers
NCT: NCT06239922 · BSERE23-APP019-ICI · 0153/2022/A