Effects of Goji vs. Fiber on Macular Degeneration
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Goji berry, Fiber.
- Who it may be relevant to
- Registry conditions: Age-Related Macular Degeneration. Basic parameters: 65 years — 95 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effects of Goji Berry Intake on Risk of Age-related Macular Degeneration: A Randomized Clinical Trial
Overview
The goal of this project is to conduct a clinical trial in 60 participants ranging from age 65-95 who are at risk for age-related macular degeneration (AMD). The study will evaluate the effects of 14g of goji berry intake or an equivalent amount and type of fiber, five days a week for six months, on visual health, gut microbiome profiles, skin carotenoid measures, and lipoprotein profiles.
Detailed description
Age-related macular degeneration (AMD) is the third leading cause of blindness worldwide. The disease occurs when the macula in the central retina develops lesions due, in part, to the loss of the protection of macular pigments zeaxanthin, lutein, and meso-zeaxanthin, which are responsible for light filtering and oxidative defense. The major risk factor for AMD is aging, and currently, no definitive prevention for AMD exists.
Goji berry (Lycium Barbarum) is a fruit that has been used as traditional medicine in Asian countries for more than 2,000 years. Modern science has identified potential benefits of the berry in oxidant defense, immune regulation, diabetes, and vision in animal and cell models. Nonetheless, evidence regarding the effects of goji berries on human health is scarce. The bioactive components of goji berries include zeaxanthin, lutein, Lycium Barbarum polysaccharides-protein complex, betaine, cerebroside, minerals, and vitamins. Importantly, goji berries contain the highest concentration of zeaxanthin among all commonly consumed foods.
Previous clinical studies have shown that goji berries have a high bioavailability of zeaxanthin, and that macular pigment optical density (MPOD) was increased after supplementation. This study uses macular pigment optical volume (MPOV; a measure that integrates MPOD across multiple macular eccentricities) as the primary outcome measure. It is unknown if the changes in MPOV will be associated with other functional changes or anatomic conditions in the eye among a population with small drusen, a risk factor for AMD. In addition, the impact of goji berry intake on the gut microbiome profile and associated metabolites is unknown, and potentially important in understanding the mechanism(s) of action.
Participants who meet the eligibility criteria will be enrolled and will be randomized 1:1 to the goji berry arm or fiber arm of the study. Over the course of approximately 180 days, participants will consume the assigned food item five days per week and attend three study visits.
Study visits will include ophthalmic imaging and testing, skin carotenoid measurements, completion of a food record, height, weight, handgrip strength, blood pressure measurement, and fasting blood collection. At 2 timepoints participants will be asked to provide a stool sample (collected within 24 hours of visit).
Interventions
- Dietary supplement Goji berry
Participants will be instructed to consume 14 grams of goji berries 5 days a week for 6 months - Dietary supplement Fiber
Participants will be instructed to consume the fiber supplements 5 days a week for 6 months
Primary outcome measures
- Macular pigment optical volume (MPOV) [Time frame: Day 0 and Day 180]
Secondary outcome measures (12)
- Stool microbiome [Time frame: Day 0 and Day 180]
- Spectral Domain-Ocular Coherence Tomography (SD-OCT) [Time frame: Day 0 and Day 180]
- Fundus autofluorescence (FAF) [Time frame: Day 0 and Day 180]
- Color Fundus Photography (CFP) [Time frame: Day 0 and Day 180]
- Microperimetry testing [Time frame: Day 0 and Day 180]
- Dark adaptometry [Time frame: Day 0 and Day 180]
- Plasma microbial metabolites [Time frame: Day 0 and Day 180]
- Plasma lutein and zeaxanthin [Time frame: Day 0 and Day 180]
- Lipoprotein profile [Time frame: Day 0 and Day 180]
- HDL particle characteristics [Time frame: Day 0 and Day 180]
- Peripheral blood mononuclear cells (PBMC) gene expression changes [Time frame: Day 0 and Day 180]
- Cognitive function [Time frame: Day 0 and Day 180]
Eligibility criteria
Inclusion criteria
- Family history of AMD
- Hyperlipidemia or managed diabetes
- 65 - 95 years of age
Exclusion criteria
- Dislike of, or allergy to, goji berries or any of the ingredients in the fiber-rich wafers and gummies (wheat, corn, oats, soy, natural orange flavor, xylitol, annatto, pectin, or other food ingredients)
- Consumption of > 2 alcoholic drinks per day
- Indications of substance or alcohol abuse
- Current or planned use of a blood thinner (e.g., Coumadin, Warfarin) at any time during study
- Use of multi-vitamin or any other supplements that contain lutein and/or zeaxanthin (if willing to stop the supplement, subject can be enrolled 6 months from stop date)
- Taking any new medications started within the past 6 months, or changes in medication regimen planned in the next 6 months (stable use greater than 6 months is not exclusionary)
- Any planned international travel during the study
- Consuming >3 servings/day of a combination of spinach, kale, lettuce, orange bell peppers, corn, parsley, squash, broccoli, pumpkin, edamame
- Regularly consuming >3 eggs/day
- Currently participating in any other interventional research study
- Diagnosed with inflammatory bowel disease, irritable bowel syndrome, other gastrointestinal disorder, undergoing cancer therapy or immunocompromised, or diagnosis of another condition where lutein, zeaxanthin and/or fiber supplementation would be contraindicated or would interfere with ability to participate in the study
- Any physical characteristic or condition that precludes ability to perform study procedures
- Medical or psychiatric condition that, in the opinion of the Investigator, would compromise study findings or prevent the participant from completing the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Supportive care
Study locations
United States · 1 center
- UC Davis Eye Center, Tschannen Eye Institute — Sacramento
Identifiers
NCT: NCT06237127 · 2082960