Peking University Birth Cohort in Weifang (PKUBC-WF)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: No Interventions.
- Who it may be relevant to
- Registry conditions: Health Problems in Pregnancy, Pregnancy Outcomes, Gestational Diabetes, Gestational Hypertension. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Peking University Birth Cohort in Weifang
Overview
The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to before 18 years old. Biological samples including peripheral blood, urine, placenta, umbilical cord, cord blood, and faeces are also collected.
Detailed description
Maternal and child health is of great concern globally. Early life phase of a fetus and infant is a critical period for the development of health and disease in the whole life. Exposure of negative environmental, nutritional and lifestyle factors in pregnant women during this period can have adverse effects on fetal and infant. In addition, for mothers, complications during pregnancy could also have a negative effect on long-term health of mothers, such as diabetes, hypertension. Thus, the Peking University Birth Cohort in Weifang is primarily aimed to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers, husbands and their children from birth to before 18 years old. Biological samples including peripheral blood, urine, placenta, umbilical cord, cord blood, and faeces samples are also collected.
Interventions
- Other No Interventions
No intervention This is an observational study without any intervention
Primary outcome measures
- Numbers and morbidity of participants with pregnancy complications [Time frame: At delivery]
- Numbers and morbidity of participants with adverse pregnancy outcomes [Time frame: At delivery]
Secondary outcome measures (10)
- Weight in kilogram changes during childhood [Time frame: At birth and age at 6 weeks, 6 months, 12 months, 2 years, 3 years, 6 years, 9 years, 12 years, 15 years, and 17 years]
- Height in centimeter changes during childhood [Time frame: At birth and age at 6 weeks, 6 months, 12 months, 2 years, 3 years, 6 years, 9 years, 12 years, 15 years, and 17 years]
- Early Child development [Time frame: Age at 6 weeks, 6 months and 12 months]
- Incidence of diabetes mellitus in women [Time frame: 6 weeks after delivery and 3 years after delivery]
- Incidence of hypertension in women [Time frame: 6 weeks after delivery and 3 years after delivery]
- Incidence of child overweight and obesity [Time frame: At birth and age at 6 weeks, 6 months, 12 months, 2 years, 3 years, 6 years, 9 years, 12 years, 15 years, and 17 years]
- Incidence of autism spectrum disorder in children [Time frame: Age at 2 years, 3 years]
- Incidence of attention-deficit/hyperactivity disorder in children [Time frame: Age at 6 years]
- Incidence of anxiety in adolescents [Time frame: Age at 9 years, 12 years, 15 years, and 17 years]
- Incidence of depression in adolescents [Time frame: Age at 9 years, 12 years, 15 years, and 17 years]
Eligibility criteria
Inclusion criteria
- Pregnant woman
- Pregnant women, 6-13\^+6 gestational weeks
- Resided in Weifang in the past half years and have no plan to move out after delivery
- Pregnant women who plan to have antenatal care and delivery in Weifang maternal\&Child Hospital.
- Pregnant women who is willing to participate in this study with informed consent
- Pregnant woman's husband
- His wife was eligible for enrollment
- He is the biological father of the child (his wife's current pregnancy)
- Pregnant women's husband who is willing to participate in this study with informed consent
- Offspring 4. Children born to pregnant women who met the inclusion criteria after enrolling in this study.
5\. Before the age of 8 years, his/her mother provided written informed consent. 6. After 8 years old, he/she agreed to continue this study and signed the informed consent.
Exclusion criteria
- Participants who cannot communicate normally.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Peking University — Beijing
Identifiers
NCT: NCT06234332 · PKUBC-WF