Speech Pattern Evaluation and Analysis for Knowledge of AD
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: TalkTracker.
- Who it may be relevant to
- Registry conditions: Wisconsin Alzheimer's Disease Research Center, Wisconsin Registry for Alzheimer's Prevention. Basic parameters: 40 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Connected Language and Speech Along the Spectrum of ADRD: Digital Assessment and Monitoring
Overview
The goal of this observational study is to validate changes in speech as a measure of cognition in individuals at increased risk of Alzheimer's disease and related dementias (ADRD). This study aims to clarify how speech may be affected by Alzheimer's disease. Participants will complete speech collection sessions and a survey at home using an iPad. Participants can expect to be in the study for 3 years.
Detailed description
Digital technology, including recorded speech, has the capability of providing a wealth of information about early changes to cognition and communication associated with developing Alzheimer's disease pathology, with the potential for highly accessible, yet low-burden measurement. In this project, researchers will recruit a subset of participants from two longitudinal, observational cohort studies enriched for individuals at risk for or living with Alzheimer's disease to record their speech at home with a mobile device, longitudinally. Our interdisciplinary team will then validate digital markers across all stages of Alzheimer's Disease and Related Dementias (ADRD), including the prodromal phase, and can enhance sensitivity and specificity of speech metrics while contributing valuable information about remote, noninvasive, and accessible assessment and disease monitoring.
Interventions
- Other TalkTracker
Participants will be asked to complete the speech collection procedures remotely/at home once per week for 8 weeks. The 8-week period of weekly remote speech collection will take place yearly for a total of 3 years. At the end of each 8-week study period for years 1-3, participants will complete a survey that asks questions about how easy/difficult the application was to use, how frustrated they felt using the application, and other usability questions.
Primary outcome measures
- Usability of remote at-home speech collection - objective [Time frame: 3 years]
- Usability of remote at-home speech collection - objective [Time frame: 3 years]
- Feasibility of remote at-home speech collection [Time frame: 3 years]
- Feasibility of remote at-home speech collection [Time frame: 3 years]
- Feasibility of remote at-home speech collection [Time frame: 3 years]
- Usability of remote at-home speech collection - subjective [Time frame: 3 years]
Secondary outcome measures (2)
- Correlation between in-clinic speech metrics and remote at-home speech metrics [Time frame: 3 years]
- Correlations between metrics from remote at-home speech and plasma amyloid-beta (pTau-217) [Time frame: 3 years]
Eligibility criteria
Inclusion criteria
- Must be enrolled in the Wisconsin Alzheimer's Disease Research Center (W-ADRC) Clinical Core or IMPACT studies, or in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
- Cognitively unimpaired or have a diagnosis of Mild Cognitive Impairment (MCI)
- Ages 40-80 years
- Completion of a W-ADRC or WRAP study visit within the past or upcoming 12 months
- Have provided W-ADRC or WRAP with blood plasma Alzheimer's Disease
Exclusion criteria
- Not actively enrolled in W-ADRC or WRAP
- Diagnosis of dementia
- Impaired capacity or unwilling to consent
- Major neurological conditions
- Speech disorders
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- University of Wisconsin — Madison
Identifiers
NCT: NCT06230783 · 2023-1740 · 1R01AG082052-01 · A534255 · SMPH/MEDICINE/GER-AD DEV · Protocol Version 2/4/2026