The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Exercise and environmental conditions.
- Who it may be relevant to
- Registry conditions: Hypoxia, Altitude. Basic parameters: 19 years — 29 years · Male.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Poland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Influence of Physical Training in Normobaric Hypoxia on Prooxidant-Antioxidant Imbalance, Inflammatory Marker Levels, Intestinal Damage Degree, and Mitochondrial Energy Release Rate in Young Non-trained Males
Overview
* Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal damage, and mitochondrial energy production rate in young sedentary males. * Applied objective: Development of practical training guidelines utilizing training in normobaric hypoxia conditions to enhance mechanisms related to oxygen transport, adaptive changes within the immune system, body's antioxidant capacity, gut permeability, substrate utilization efficiency, and mitochondrial function for coaches and athletes.
Interventions
- Other Exercise and environmental conditions
Participants will engage in interval training and will reside and sleep at different altitudes for a period of 4 weeks. Aerobic and anaerobic capacity tests and an eccentric exercise test will be performed before and after the training intervention. Before and after the training program, somatic measurements will also be taken. Before and after the first and last workout, blood will be drawn for biochemical analysis.
Primary outcome measures
- Measurement of aerobic capacity (endurance) [Time frame: 7 days before training and 7-10 days after the training. Training will last 4 weeks.]
- Measurement of anaerobic capacity [Time frame: 7 days before training and 7-10 days after the training. Training will last 4 weeks]
- Blood analysis [Time frame: 7 days before training and 7- 10 days after the training. The training will last 4 weeks and will consist of 12 workouts.]
- Somatic indices [Time frame: 7 days before training and 7-10 days after the training. Training will last 4 weeks.]
Eligibility criteria
Inclusion criteria
- no known metabolic diseases, no contraindications to physical exercise and no history of high altitude sickness stated in interview. A medical examination (including ECG, blood and urine tests) is required.
Exclusion criteria
- changes in diet during the experiment, smoking and abuse of alcohol and/or other stimulants.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
Poland · 1 center
- University School of Physical Education in Cracow — Krakow
Identifiers
NCT: NCT06204731 · SKN/SP/570048/2023