Anti-bacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Calcium hydroxide, nano calcium hydroxide.
- Who it may be relevant to
- Registry conditions: Endodontic Disease, Pulp Disease, Dental. Basic parameters: 21 years — 49 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Evaluation of the Antibacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication: A Randomized Clinical Trial
Overview
The aim of the study is to evaluate the anti-bacterial potential of Nano Calcium Hydroxide as an intracanal medication in primary endodontic treatment of permanent molars.
Detailed description
This study is conducted to evaluate the bacterial reduction capability of hydrogel loaded with Nano Calcium Hydroxide and paste form of nano and conventional calcium hydroxide as an intracanal medication. The hydrogel will be synthesized in a new rapid in situ form that can turn from liquid into gel when reaching body temperature. The efficacy of bacterial reduction will be compared with Nano Calcium Hydroxide and conventional Calcium Hydroxide in paste form. The evaluation is to be done by quantitative microbiological assessment of samples which are gained from the root canal before and after intracanal medication placement in roots of permanent molars, having PAI score ≥ 2.
Interventions
- Drug Calcium hydroxide
placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week. - Drug nano calcium hydroxide
placement of intracanal medication for the three groups will be done after cleaning and shaping of the root canals and it will be left for one week.
Primary outcome measures
- bacterial count [Time frame: on the seventh day from intercanal medication placement appointment]
Secondary outcome measures (3)
- periapical healing [Time frame: participants will be recalled after 6 months from the obturation for radiographic examination]
- incidence and intensity of pain [Time frame: Pain intensity will be assessed each day for three days following initial treatment]
- incidence of flare up [Time frame: incidence of flare up will be recorded each day after the intracanal medication placment visit until the next visit (after seven days)]
Eligibility criteria
Inclusion criteria
- healthy males and females.
- age range between 21-49.
- patients with no physical disability or psychological problems.
- patients presenting with single permanent molar with signs and/or symptoms of apical periodontitis, and having Periapican index ≥ 2.
Exclusion criteria
- pregnant women.
- patients with immune-compromised disease.
- patients with complicated systemic diseases.
- patients who took antibiotics within a period of 1 month.
- patients with known sensitivity to the medicaments or pharmaceuticals used in this study.
- Non-restorable teeth including root fractures, and/or advanced periodontal involvement.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- british university in Egypt - dentistry collage — Cairo
Identifiers
NCT: NCT06196515 · 23-041