Contrast Echocardiography During Exercise to Assess Pulmonary Blood Volume
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Heart Failure, Pulmonary Vascular Disease. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Assessment of Pulmonary Blood Volume Using Contrast Echocardiography During Exercise
Overview
The purpose of this study is to evaluate whether pulmonary blood volume (PBV) derived from contrast echocardiography can serve as a non-invasive surrogate for invasive pulmonary artery wedge pressure (PAWP) during exercise. Also, to compare changes in PBV with exercise in patients with and without heart failure and pulmonary vascular disease.
Primary outcome measures
- Pulmonary Vascular Capacitance at Rest [Time frame: Baseline]
- Pulmonary Vascular Capacitance During Exercise [Time frame: Baseline]
Secondary outcome measures (12)
- Pulmonary Blood Volume at Rest [Time frame: Baseline]
- Pulmonary Blood Volume During Exercise [Time frame: Baseline]
- Pulmonary Vascular Compliance at Rest [Time frame: Baseline]
- Pulmonary Vascular Compliance During Exercise [Time frame: Baseline]
- Right Atrial Pressure at Rest [Time frame: Baseline]
- Right Atrial Pressure During Exercise [Time frame: Baseline]
- Right Ventricular Pressure at Rest [Time frame: Baseline]
- Right Ventricular Pressure During Exercise [Time frame: Baseline]
- Pulmonary Artery Pressure at Rest [Time frame: Baseline]
- Pulmonary Artery Pressure During Exercise [Time frame: Baseline]
- Pulmonary Capillary Wedge Pressure at Rest [Time frame: Baseline]
- Pulmonary Capillary Wedge Pressure During Exercise [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
- Patients referred to the cardiac catheterization laboratory for invasive exercise right heart catheterization for evaluating exertional dyspnea. Investigators will include patients with normal or low EF, and across the spectrum of pulmonary hypertension severity.
Exclusion criteria
- Patient inability or unwillingness to undergo echocardiography including a contrast method, or if echocardiography would, in the opinion of the investigator, somehow compromise the quality of data acquisition for the clinical case.
- Prior adverse reaction to echo contrast administration
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- Mayo Clinic in Rochester — Rochester
Identifiers
NCT: NCT06195059 · 23-009478